Association of biochemical hyperandrogenism with type 2 diabetes and obesity in Chinese women with polycystic ovary syndrome

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
Xiaomiao ZhaoDongzi Yang

Abstract

To evaluate the effect of hyperandrogenism on metabolic disorders among patients with polycystic ovary syndrome (PCOS) diagnosed using the Rotterdam criteria. A retrospective analysis of the clinical records of 883 women with PCOS and 717 premenopausal controls identified from the general population. A total of 686 (77.7%) patients were classified with PCOS based on National Institutes of Health (NIH) criteria, and 164 out of 197 (83.2%) additional patients had no hyperandrogenism. Women with normal androgen levels exhibited lower frequencies of obesity, type 2 diabetes, acanthosis nigricans, genetic history of diabetes, and elevated Matsuda index compared with hyperandrogenic patients. Hyperandrogenemia, but not hirsutism, was independently associated with the risk for type 2 diabetes (odds ratio [OR] 5.7; P=0.028) and obesity (OR 1.7; P=0.005) among Chinese patients with PCOS. Hyperandrogenemia is associated with type 2 diabetes and obesity in Chinese women with PCOS and should be considered at first-line management of hyperandrogenism and infertility due to PCOS.

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Citations

Dec 8, 2011·Human Reproduction·UNKNOWN Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group
Jan 8, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Fahimeh Ramezani TehraniFereidoun Azizi
Oct 24, 2012·Journal of Pediatric and Adolescent Gynecology·Lin LiDongzi Yang
Oct 1, 2012·Obesity Research & Clinical Practice·Liang-Jun Xie, Mu-Hua Cheng
Jul 19, 2011·Fertility and Sterility·Xiaomiao ZhaoDongzi Yang
Sep 27, 2014·The Journal of Obstetrics and Gynaecology Research·Yavuz M GözükaraPelin Aytan
Nov 30, 2010·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Xiaomiao ZhaoDongzi Yang
Jun 13, 2016·Best Practice & Research. Clinical Obstetrics & Gynaecology·Zhongwei Huang, Eu-Leong Yong
Jan 1, 2013·Expert Review of Endocrinology & Metabolism·Chandrika N WijeyaratneAdam H Balen

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