Association of biomarkers of systemic inflammation with organic components and source tracers in quasi-ultrafine particles.

Environmental Health Perspectives
Ralph J DelfinoConstantinos Sioutas

Abstract

Evidence is needed regarding the air pollutant components and their sources responsible for associations between particle mass concentrations and human cardiovascular outcomes. We previously found associations between circulating biomarkers of inflammation and mass concentrations of quasi-ultrafine particles <or= 0.25 microm in aerodynamic diameter (PM0.25) in a panel cohort study of 60 elderly subjects with coronary artery disease living in the Los Angeles Basin. We reassessed biomarker associations with PM0.25 using new particle composition data. Weekly biomarkers of inflammation were plasma interleukin-6 (IL-6) and soluble tumor necrosis factor-alpha receptor II (sTNF-RII) (n = 578). Exposures included indoor and outdoor community organic PM0.25 constituents [polycyclic aromatic hydrocarbons (PAHs), hopanes, n-alkanes, organic acids, water-soluble organic carbon, and transition metals]. We analyzed the relation between biomarkers and exposures with mixed-effects models adjusted for potential confounders. Indoor and outdoor PAHs (low-, medium-, and high-molecular-weight PAHs), followed by hopanes (vehicle emissions tracer), were positively associated with biomarkers, but other organic components and transition metals were not...Continue Reading

References

Jul 9, 2004·Environmental Health Perspectives·Chang-Chuan ChanLian-Yu Lin
Dec 17, 2004·The New England Journal of Medicine·Jennifer K PaiEric B Rimm
Feb 8, 2005·The Journal of Allergy and Clinical Immunology·Marc Riedl, David Diaz-Sanchez
Apr 7, 2005·Environmental Health Perspectives·Alexandra HennebergerAnnette Peters
Apr 12, 2005·Cardiovascular Research·Stephen B KritchevskyMarco Pahor
Jul 9, 2005·Environmental Health Perspectives·Günter OberdörsterJan Oberdörster
Aug 5, 2005·Environmental Health Perspectives·Ralph J DelfinoShaista Malik
Aug 5, 2005·Environmental Health Perspectives·Constantinos SioutasManisha Singh
Nov 3, 2005·Environmental Health Perspectives·Peter S VinzentsSteffen Loft
Nov 16, 2005·Circulation·Stephanie von KlotUNKNOWN Health Effects of Particles on Susceptible Subpopulations (HEAPSS) Study Group
Nov 19, 2005·American Journal of Respiratory and Critical Care Medicine·Regina RückerlAnnette Peters
Mar 31, 2006·Environmental Science & Technology·Jorn D HernerMichael J Kleeman
Jun 30, 2006·Journal of the Air & Waste Management Association·Judith C Chow
Jun 30, 2006·Journal of the Air & Waste Management Association·C Arden Pope, Douglas W Dockery
Mar 3, 2007·Science·Allen L RobinsonSpyros N Pandis
Jun 9, 2007·Particle and Fibre Toxicology·Leonidas NtziachristosConstantinos Sioutas
Oct 13, 2007·American Journal of Respiratory and Critical Care Medicine·Winfried MöllerWolfgang G Kreyling
Nov 2, 2007·Journal of the Air & Waste Management Association·Glynis C LoughPeter A Gabele
Jul 22, 2008·Swiss Medical Weekly·Christian MühlfeldBarbara Rothen-Rutishauser
Oct 17, 2008·Annals of Epidemiology·Holly JanesKristen Shepherd
Nov 26, 2008·Nature Clinical Practice. Cardiovascular Medicine·Nicholas L MillsDavid E Newby
Mar 21, 2009·American Journal of Respiratory and Critical Care Medicine·Michelle L BellFrancesca Dominici
May 26, 2009·American Journal of Epidemiology·Gemma Flores-MateoMaría-Isabel Covas

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Citations

Dec 25, 2013·BMC Public Health·Esmée BijnensTim S Nawrot
May 21, 2013·Toxicology and Applied Pharmacology·Andrea L KnechtRobert L Tanguay
Apr 15, 2014·Environmental Science and Pollution Research International·Qingyang LiuMeigen Zhang
Dec 6, 2014·Mutation Research. Reviews in Mutation Research·Peter MøllerSteffen Loft
Jul 4, 2013·Environmental Health Perspectives·Elissa H WilkerDavid Sparrow
Mar 1, 2011·Air Quality, Atmosphere, & Health·Ralph J DelfinoNosratola D Vaziri
Apr 28, 2011·Journal of Exposure Science & Environmental Epidemiology·Richard E PeltierMorton Lippmann
Nov 1, 2011·Analytical and Bioanalytical Chemistry·Ralf Zimmermann
Jul 13, 2012·Environmental Health : a Global Access Science Source·Jun WuRalph J Delfino
Jun 21, 2013·Environmental Health : a Global Access Science Source·Hind SbihiMichael Brauer
Aug 29, 2013·Environmental Health : a Global Access Science Source·Marianthi-Anna KioumourtzoglouHelen H Suh
Jan 8, 2015·Journal of Exposure Science & Environmental Epidemiology·Sharine WittkoppRalph J Delfino
Dec 9, 2015·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·James ClarkBastiaan Hoogendoorn
Mar 15, 2016·Frontiers in Immunology·Kathleen A StringerPaige Lacy
May 8, 2013·Environmental Toxicology·Yasuhiro ShinkaiYoshito Kumagai
Oct 17, 2015·The Science of the Total Environment·Farimah ShirmohammadiConstantinos Sioutas
Apr 2, 2015·Journal of Exposure Science & Environmental Epidemiology·Kevin J LaneDoug Brugge
Nov 20, 2012·Toxicology in Vitro : an International Journal Published in Association with BIBRA·E LonghinM Gualtieri
Nov 13, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Laura S Van WinkleAnthony S Wexler
Dec 19, 2013·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Arian SaffariConstantinos Sioutas
Dec 17, 2014·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Beatriz Fátima Alves de OliveiraSandra Hacon
Mar 30, 2017·The Science of the Total Environment·Sasan FaridiMasud Yunesian
Mar 28, 2017·Toxicology Letters·Hyoung-June KimDong Wook Shin
Dec 17, 2016·Epidemiology·Dongni YeStefanie Ebelt Sarnat
Jul 18, 2015·International Journal of Environmental Research and Public Health·Luz T Padró-MartínezJohn L Durant
Oct 7, 2010·Epidemiology·Bert Brunekreef
Aug 26, 2011·Inhalation Toxicology·Regina RückerlAnnette Peters
Mar 29, 2013·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Timothy ElvidgeBastiaan Hoogendoorn

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