Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes.

Cell Metabolism
Lihua ZhuHongliang Li

Abstract

Type 2 diabetes (T2D) is a major comorbidity of COVID-19. However, the impact of blood glucose (BG) control on the degree of required medical interventions and on mortality in patients with COVID-19 and T2D remains uncertain. Thus, we performed a retrospective, multi-centered study of 7,337 cases of COVID-19 in Hubei Province, China, among which 952 had pre-existing T2D. We found that subjects with T2D required more medical interventions and had a significantly higher mortality (7.8% versus 2.7%; adjusted hazard ratio [HR], 1.49) and multiple organ injury than the non-diabetic individuals. Further, we found that well-controlled BG (glycemic variability within 3.9 to 10.0 mmol/L) was associated with markedly lower mortality compared to individuals with poorly controlled BG (upper limit of glycemic variability exceeding 10.0 mmol/L) (adjusted HR, 0.14) during hospitalization. These findings provide clinical evidence correlating improved glycemic control with better outcomes in patients with COVID-19 and pre-existing T2D.

Associated Clinical Trials

References

May 8, 2003·JAMA : the Journal of the American Medical Association·Christopher M BoothAllan S Detsky
Dec 4, 2003·Intensive Care Medicine·Barbara J PhilipsEmma H Baker
Feb 3, 2006·The New England Journal of Medicine·Greet Van den BergheRoger Bouillon
Jun 9, 2006·Diabetic Medicine : a Journal of the British Diabetic Association·J K YangJ C N Chan
Mar 26, 2013·Journal of Thrombosis and Haemostasis : JTH·S GandoUNKNOWN Scientific and Standardization Committee on DIC of the International Society on Thrombosis and Haemostasis (ISTH)
Aug 3, 2013·BMJ Open·Akbar K WaljeePeter Dr Higgins
May 26, 2017·Immunology·Pavan Kumar Nathella, Subash Babu
Jun 28, 2017·JAMA : the Journal of the American Medical Association·Limin WangLinhong Wang
Jul 12, 2017·Annals of Internal Medicine·Tyler J VanderWeele, Peng Ding
Jun 19, 2018·Epidemiology·Maya B MathurTyler J VanderWeele
Dec 20, 2018·Physiological Reviews·Meng XuHongliang Li
Jan 25, 2019·JAMA : the Journal of the American Medical Association·Sebastien HaneuseDavid Arterburn
Mar 26, 2019·Diabetes/metabolism Research and Reviews·Leonello FusoRaffaele Antonelli-Incalzi
Nov 7, 2019·BMJ : British Medical Journal·René Rodriguez-GutierrezRozalina G McCoy
Jan 25, 2020·The New England Journal of Medicine·Na ZhuUNKNOWN China Novel Coronavirus Investigating and Research Team
Feb 26, 2020·Journal of Clinical Medicine·Sheng-Qun Deng, Hong-Juan Peng
Feb 29, 2020·The New England Journal of Medicine·Wei-Jie GuanUNKNOWN China Medical Treatment Expert Group for Covid-19

❮ Previous
Next ❯

Citations

Jun 9, 2020·Expert Review of Endocrinology & Metabolism·Thomas M Barber
Jun 13, 2020·Molecular Nutrition & Food Research·Hugo Charles-Messance, Frederick J Sheedy
Jun 11, 2020·Journal of Diabetes Investigation·Keiko Naruse
Jun 17, 2020·Diabetes Care·Elizabeth Selvin, Stephen P Juraschek
Jun 18, 2020·Diabetes Care·Jamie Hartmann-BoyceKamlesh Khunti
Jun 28, 2020·Diabetes/metabolism Research and Reviews·Stefano Balducci, Eliana M Coccia
Jul 22, 2020·BMJ Open Diabetes Research & Care·Unjali P GujralFrancisco J Pasquel
Aug 5, 2020·Acta Diabetologica·Bartolomeu Fagundes de Lima FilhoFabricia Azevedo da Costa Cavalcanti
May 30, 2020·Aging·Amber L MuellerDavid A Sinclair
Aug 19, 2020·Molecular Neurobiology·Jasvinder Singh BhattiP Hemachandra Reddy
Sep 1, 2020·Acta Diabetologica·Giuseppe PuglieseEmanuela Orsi
Jul 17, 2020·Journal of Diabetes·Aman RajpalFaramarz Ismail-Beigi
Sep 5, 2020·Seminars in Liver Disease·Maria J Lizardo-ThiebaudNalu Navarro-Alvarez
Sep 17, 2020·Infectious Diseases and Therapy·Grant W Waterer, Jordi Rello
Sep 2, 2020·Diabetes, Obesity & Metabolism·Ming Hui LeeChin Meng Khoo
Aug 12, 2020·Diabetes·Roma GianchandaniRodica Pop-Busui
Jul 4, 2020·Diabetes Care·Abu Saleh Md MoinAlexandra E Butler
Aug 21, 2020·Endocrinology and Metabolism·Norbert Stefan
Sep 8, 2020·The British Journal of Nutrition·Laura E GleesonFrederick J Sheedy
Jun 18, 2020·Minerva endocrinologica·Subhankar ChatterjeeSanjay Kalra
Oct 4, 2020·Journal of Orthopaedic Surgery and Research·Haiying ZhouHui Lu
Jun 4, 2020·Diabetes/metabolism Research and Reviews·Amin Yehya, Salvatore Carbone
Jul 15, 2020·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·David M WilliamsMarc Evans
Jul 22, 2020·Cardiovascular Diabetology·Antonio CerielloUNKNOWN “Diabetes and Cardiovascular Disease (D&CVD)” Study Group of the European Association for the Study of Diabetes (EASD)
Jul 12, 2020·BMJ Evidence-based Medicine·Maryanne Demasi
Jul 31, 2020·Journal of the Endocrine Society·Noel Pratheepan SomasundaramAshley Barry Grossman
Aug 17, 2020·Diabetes/metabolism Research and Reviews·Amit AkirovItamar Raz
Aug 9, 2020·Journal of Diabetes Science and Technology·Angelo CignarelliFrancesco Giorgino

❮ Previous
Next ❯

Software Mentioned

missForest
R
SPSS Statistics
MatchIt

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.