Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes.

Cell Metabolism
Lihua ZhuHongliang Li


Type 2 diabetes (T2D) is a major comorbidity of COVID-19. However, the impact of blood glucose (BG) control on the degree of required medical interventions and on mortality in patients with COVID-19 and T2D remains uncertain. Thus, we performed a retrospective, multi-centered study of 7,337 cases of COVID-19 in Hubei Province, China, among which 952 had pre-existing T2D. We found that subjects with T2D required more medical interventions and had a significantly higher mortality (7.8% versus 2.7%; adjusted hazard ratio [HR], 1.49) and multiple organ injury than the non-diabetic individuals. Further, we found that well-controlled BG (glycemic variability within 3.9 to 10.0 mmol/L) was associated with markedly lower mortality compared to individuals with poorly controlled BG (upper limit of glycemic variability exceeding 10.0 mmol/L) (adjusted HR, 0.14) during hospitalization. These findings provide clinical evidence correlating improved glycemic control with better outcomes in patients with COVID-19 and pre-existing T2D.

Associated Clinical Trials


May 8, 2003·JAMA : the Journal of the American Medical Association·Christopher M BoothAllan S Detsky
Dec 4, 2003·Intensive Care Medicine·Barbara J PhilipsEmma H Baker
Feb 3, 2006·The New England Journal of Medicine·Greet Van den BergheRoger Bouillon
Jun 9, 2006·Diabetic Medicine : a Journal of the British Diabetic Association·J K YangJ C N Chan
Mar 26, 2013·Journal of Thrombosis and Haemostasis : JTH·S GandoUNKNOWN Scientific and Standardization Committee on DIC of the International Society on Thrombosis and Haemostasis (ISTH)
Aug 3, 2013·BMJ Open·Akbar K WaljeePeter Dr Higgins
May 26, 2017·Immunology·Pavan Kumar Nathella, Subash Babu
Jun 28, 2017·JAMA : the Journal of the American Medical Association·Limin WangLinhong Wang
Jul 12, 2017·Annals of Internal Medicine·Tyler J VanderWeele, Peng Ding
Jun 19, 2018·Epidemiology·Maya B MathurTyler J VanderWeele
Dec 20, 2018·Physiological Reviews·Meng XuHongliang Li
Jan 25, 2019·JAMA : the Journal of the American Medical Association·Sebastien HaneuseDavid Arterburn
Mar 26, 2019·Diabetes/metabolism Research and Reviews·Leonello FusoRaffaele Antonelli-Incalzi
Nov 7, 2019·BMJ : British Medical Journal·René Rodriguez-GutierrezRozalina G McCoy
Jan 25, 2020·The New England Journal of Medicine·Na ZhuUNKNOWN China Novel Coronavirus Investigating and Research Team
Feb 26, 2020·Journal of Clinical Medicine·Sheng-Qun Deng, Hong-Juan Peng
Feb 29, 2020·The New England Journal of Medicine·Wei-Jie GuanUNKNOWN China Medical Treatment Expert Group for Covid-19

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