Association of blood lead (Pb) and plasma homocysteine: a cross sectional survey in Karachi, Pakistan.

PloS One
Mohsin Yakub, Mohammad Perwaiz Iqbal

Abstract

High blood lead (Pb) and hyperhomocysteinemia have been found to be associated with cardiovascular disease (CVD). Mean blood Pb and mean plasma homocysteine levels have been reported to be high in Pakistani population. The objective of the present study was to assess the relationship of blood Pb to the risk of hyperhomocysteinemia in a low income urban population of Karachi, Pakistan. In a cross sectional survey, 872 healthy adults (355 males, 517 females; age 18-60 years) were recruited from a low income urban population of Karachi. Fasting venous blood was obtained and assessed for blood Pb and plasma/serum homocysteine, folate, pyridoxal phosphate (PLP, a coenzymic form of vitamin B6) and vitamin B12. The study population had median (IQR) blood Pb of 10.82 microg/dL (8.29-13.60). Prevalence of high blood Pb (levels>10 microg/dL) was higher in males compared to females (62.5% males vs 56% females; p value=0.05). Mean+/-SD/median (IQR) value of plasma homocysteine was significantly higher in the highest quartile of blood Pb compared to the lowest quartile 16.13+/-11.2 micromol/L vs 13.28+/-9.7micromol/L/13.15 (10.33-17.81) micromol/L vs 11.09 (8.65 14.31) micromol/L (p value<0.001). Daily consumption of fruit juice had a posit...Continue Reading

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Citations

Feb 14, 2014·Environmental Science and Pollution Research International·Xia HuoXijin Xu
Dec 12, 2012·Journal of Preventive Medicine and Public Health = Yebang Ŭihakhoe Chi·Yu-Mi LeeDuk-Hee Lee
Mar 22, 2014·Journal of Occupational Medicine and Toxicology·Higemengist A GebrieArgaw Ambelu
Jan 1, 2014·PloS One·Mohammad Perwaiz Iqbal, Mohsin Yakub
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Aug 5, 2017·Occupational and Environmental Medicine·Kyoung-Nam KimYun-Chul Hong
Jan 8, 2020·Antioxidants·Caterina LeddaVenerando Rapisarda

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Software Mentioned

Statistical Package for Social Sciences® ( SPSS )

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