Association of blood pressure and its evolving changes with the survival of patients with heart failure

Journal of Cardiac Failure
Lilian Grigorian-ShamagianMuerte Subita En La Insuficiencia Cardiaca (MUSIC) Group

Abstract

The association between low blood pressure (BP) levels and increased mortality has been established in several studies of heart failure (HF). Although many drugs administered to these patients decrease BP, the relationship between changes in BP and survival has not been investigated. Nor have previous analyses distinguished among different forms of death. We investigated the influence of baseline BP and changes in BP during a 1-year period on the survival of patients with HF, distinguishing among sudden cardiac death, nonsudden cardiac death, and noncardiac death. We also identified the possible relationship with the baseline values of and changes in other clinical and treatment variables, including pharmacologic treatments. A total of 1062 patients with chronic HF included in the Spanish National Registry of Sudden Death (mean age of 64.5 +/- 11.8 years, 72% were men, and 21% were in New York Heart Association class III with a mean left ventricular ejection fraction of 36.7% +/- 14.2%) were prospectively investigated for a mean of 1.9 +/- 0.6 years. A multivariable Cox proportional hazards model adjusting for clinical and therapeutic variables showed an independent association between low baseline systolic blood pressure (SBP)...Continue Reading

References

Jan 23, 1992·The New England Journal of Medicine·A E Fletcher, C J Bulpitt
Jan 23, 1991·JAMA : the Journal of the American Medical Association·L FarnettM R Tuley
May 16, 2003·JAMA : the Journal of the American Medical Association·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
Nov 20, 2003·JAMA : the Journal of the American Medical Association·Douglas S LeeJack V Tu
Apr 14, 2005·European Heart Journal·Michel KomajdaClaude Le Pen
Dec 22, 2005·American Heart Journal·Tobias T LeeLana Tsao
Nov 9, 2006·JAMA : the Journal of the American Medical Association·Mihai GheorghiadeUNKNOWN OPTIMIZE-HF Investigators and Coordinators

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Citations

Aug 20, 2010·Journal of Hypertension·Miklos Z MolnarKamyar Kalantar-Zadeh
Aug 18, 2010·The Journal of Cardiovascular Nursing·Mary Murphy
May 28, 2009·Journal of the American Geriatrics Society·Dae Hyun Kim, Ihab Hajjar
Jan 20, 2010·European Journal of Heart Failure·María T VidánHarlan M Krumholz

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