Association of BoLA-DRB3 alleles with mastitis resistance and susceptibility in Japanese Holstein cows

Animal Science Journal = Nihon Chikusan Gakkaihō
Tatsuyuki YoshidaH Mukoyama

Abstract

In this study, 714 cows from 26 dairy herds were reclassified as healthy or mastitic cows on the basis of long-term somatic cell count (SCC) in milk. Cows with more than three consecutive lactation records of SCC from the first or second to fifth lactation, were selected, and their BoLA-DRB3 (DRB3) alleles were identified using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Cows with an SCC of < 200 000 cells/mL in all monthly records were classified as healthy (n=91). Cows with an SCC of > 300 000 cells/mL in two consecutive tests or four non-consecutive tests or cows with an SCC of > 500 000 cells/mL in any one test during lactation, regardless of parity, were classified as mastitic (n=201). Mastitic cows (n=153) from another 40 herds were considered to be infected if bacteriological testing revealed mastitis pathogens in milk. Their DRB3 alleles were identified using PCR-sequence-based typing (PCR-SBT). The differences in DRB3 allelic frequencies between healthy cows and cows with various degrees of mastitis were re-investigated. Moreover, the associations of various amino acid motifs in DRB3 alleles with resistance or susceptibility to mastitis pathogens were re-examined. DRB3.2*8(DRB3...Continue Reading

References

Jan 1, 1992·Animal Genetics·M J van EijkH A Lewin
Aug 5, 2004·Journal of Dairy Science·M J GreenG F Medley
Feb 19, 2010·Animal Science Journal = Nihon Chikusan Gakkaihō·Tatsuyuki YoshidaHiroshi Tomogane
Feb 19, 2010·Animal Science Journal = Nihon Chikusan Gakkaihō·Tatsuyuki YoshidaHiroshi Tomogane

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Citations

Oct 24, 2014·Frontiers in Immunology·Kathleen Thompson-CrispiBonnie A Mallard
May 29, 2018·Veterinary World·V BhanuprakashManjit Panigrahi
Sep 8, 2017·Frontiers in Genetics·Maulik UpadhyayRichard P M A Crooijmans
Apr 1, 2021·Tropical Animal Health and Production·Amr El-Sayed, Mohamed Kamel

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