PMID: 9431951Feb 12, 1998Paper

Association of borderline oxacillin-susceptible strains of Staphylococcus aureus with surgical wound infections

Journal of Clinical Microbiology
D S KernodleA B Kaiser

Abstract

Staphylococcus aureus isolates which produce type A staphylococcal beta-lactamase have been associated with wound infections complicating the use of cefazolin prophylaxis in surgery. To further evaluate this finding, 215 wound isolates from 14 cities in the United States were characterized by antimicrobial susceptibility and beta-lactamase type and correlated with the preoperative prophylactic regimen. Borderline-susceptible S. aureus isolates of phage group 5 (BSSA-5), which produce large amounts of type A beta-lactamase and exhibit borderline susceptibility to oxacillin, comprised a greater percentage of the 120 wound isolates associated with cefazolin prophylaxis than they did of the 95 isolates associated with other prophylactic regimens (25% versus 12.6%, respectively; P < 0.05). In contrast, methicillin-resistant S. aureus isolates were distributed evenly between the two groups (8.3% versus 11.6%, respectively). In vitro assays demonstrated that cefazolin was hydrolyzed faster by BSSA-5 strains than by other beta-lactamase-producing, methicillin-susceptible strains (1.54 versus 0.50 microg/min/10(8) CFU, respectively; P < 0.0001). These data demonstrate that BSSA-5 strains are a distinct subpopulation of methicillin-susce...Continue Reading

References

Feb 1, 1992·Antimicrobial Agents and Chemotherapy·D J ZygmuntD S Kernodle
Sep 16, 1991·The American Journal of Medicine·D R SchabergR P Gaynes
Jan 1, 1989·The Journal of Infectious Diseases·D S KernodleP A McGraw
Feb 1, 1988·The Journal of Infectious Diseases·D S KernodleA B Kaiser
Feb 1, 1985·The Journal of Antimicrobial Chemotherapy·N Frimodt-MøllerF Espersen
Dec 1, 1988·Antimicrobial Agents and Chemotherapy·J G Sierra-MaderoJ A Washington
Sep 1, 1993·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·P E VaraldoF Santacroce
Apr 1, 1996·Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology·C CunyW Witte
Mar 1, 1965·The Biochemical Journal·M H RICHMOND

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Citations

Jan 5, 2002·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·R Sá-LeãoH de Lencastre
Oct 15, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Esteban C NanniniBarbara E Murray
Jul 21, 2012·Journal of Clinical Microbiology·Senda Mezghani MaalejAdnene Hammami
Sep 13, 2017·Journal of Medical Microbiology·Maria M Hryniewicz, Katarzyna Garbacz

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