Association of breast cancer resistance protein/ABCG2 phenotypes and novel promoter and intron 1 single nucleotide polymorphisms

Drug Metabolism and Disposition : the Biological Fate of Chemicals
Balasubramanian PoonkuzhaliErin G Schuetz

Abstract

The hypothesis was tested that sequence diversity in breast cancer resistance protein (BCRP)'s cis-regulatory region is a significant determinant of BCRP expression. The BCRP promoter and intron 1 were resequenced in lymphoblast DNA from the polymorphism discovery resource (PDR) 44 subset. BCRP single nucleotide polymorphisms (SNPs) were genotyped in donor human livers, intestines, and lymphoblasts quantitatively phenotyped for BCRP mRNA expression. Carriers of the -15622C>T SNP had lower BCRP expression in multiple tissues. The intron 1 SNP 16702C>T was associated with high expression in livers; 1143G>A was associated with low expression in intestine; 12283T>C was associated with higher expression in the PDR44 and White livers. The -15994C>T promoter SNP was significantly associated with higher BCRP expression in multiple tissues. Patients with the -15994C>T genotype had substantially higher clearance of p.o. imatinib. We next determined whether BCRP expression was related to polymorphic alternative splicing or alternative promoter use. Liver polymorphically expressed an alternatively spliced mRNA [splice variant (SV) 1] skipping exon 2. Although SV1+ livers did not uniformly carry the exon 2 G34A allele, 90% of G34A livers ex...Continue Reading

References

Apr 16, 2003·British Journal of Haematology·Aloysius Y L HoGhulam J Mufti
Mar 27, 2004·The Journal of Biological Chemistry·Partha KrishnamurthyJohn D Schuetz
May 25, 2004·Molecular Pharmacology·Csilla Ozvegy-LaczkaBalázs Sarkadi
Jul 2, 2004·Clinical Pharmacology and Therapeutics·Alex SparreboomHoward L McLeod
Sep 10, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Floris A de JongHoward L McLeod
Oct 12, 2004·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Daisuke KobayashiYuichi Sugiyama
Nov 24, 2004·Pharmaceutical Research·Chihiro KondoYuichi Sugiyama
Apr 2, 2005·British Journal of Clinical Pharmacology·Qingyu ZhouBalram Chowbay
May 12, 2005·Journal of Mammary Gland Biology and Neoplasia·Matthew J Smalley, Robert B Clarke
Jan 18, 2006·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Henriette E Meyer zu SchwabedissenHeyo K Kroemer
May 19, 2006·Pharmacogenetics and Genomics·Jatinder K LambaErin G Schuetz
Aug 8, 2006·Clinical Pharmacology and Therapeutics·Erin R GardnerKees Nooter
Sep 7, 2006·Molecular and Cellular Biology·Kenneth K W ToSusan E Bates
Nov 24, 2006·Nature·Richard RedonMatthew E Hurles
Dec 6, 2006·Molecular and Cellular Biology·Antonius E van HerwaardenAlfred H Schinkel
Feb 23, 2007·American Journal of Physiology. Cell Physiology·Johan W JonkerAlfred H Schinkel
Apr 25, 2007·BMC Developmental Biology·Alistair J WattStephen A Duncan

❮ Previous
Next ❯

Citations

Feb 2, 2013·Clinical Pharmacokinetics·Muriel NoetzliChin B Eap
Aug 22, 2009·Journal of Human Genetics·Pei-Chieng ChaYusuke Nakamura
Jan 15, 2009·The Journal of Pharmacology and Experimental Therapeutics·Harunobu TaharaKathleen M Giacomini
Dec 30, 2009·Pharmacological Reviews·Marleen WelshM Eileen Dolan
Aug 7, 2008·Pharmacogenomics·George Cusatis, Alex Sparreboom
Jan 29, 2014·Medical Oncology·Luciene Terezina de LimaElvira M Guerra-Shinohara
Aug 13, 2008·Analytical and Bioanalytical Chemistry·Ulrich M ZangerMatthias Schwab
Aug 28, 2014·Expert Opinion on Drug Metabolism & Toxicology·Oliver Bruhn, Ingolf Cascorbi
Jan 18, 2012·Biochemical Pharmacology·Karthika NatarajanDouglas D Ross
Sep 12, 2009·The Journal of Steroid Biochemistry and Molecular Biology·Maria GiessOliver Treeck
Dec 30, 2008·Advanced Drug Delivery Reviews·Kohji NoguchiYoshikazu Sugimoto
Jun 8, 2012·Drug Metabolism and Pharmacokinetics·Tomoyuki MizunoToshiya Katsura
Jun 2, 2015·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Elena De MattiaGiuseppe Toffoli
Jul 8, 2016·Journal of Clinical Pharmacology·Cheynne McLeanRichard B Kim
Oct 25, 2016·Trends in Pharmacological Sciences·Claudia NeulAnne T Nies
Feb 2, 2018·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Kristin M BircsakLauren M Aleksunes
Nov 20, 2016·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Rachel J EclovDeanna L Kroetz
Feb 23, 2018·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Rachel J EclovDeanna L Kroetz
Sep 30, 2018·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Niall HeyesIan D Kerr
Aug 12, 2014·World Journal of Gastroenterology : WJG·Mariusz Panczyk
Sep 21, 2017·Pharmacogenetics and Genomics·Rachel J EclovDeanna L Kroetz
Aug 16, 2019·World Journal of Gastroenterology : WJG·Elena De MattiaGiuseppe Toffoli
Jan 19, 2021·Expert Opinion on Drug Metabolism & Toxicology·Henrike Bruckmueller, Ingolf Cascorbi
Apr 4, 2021·International Journal of Molecular Sciences·László Homolya
Sep 30, 2021·Cellular and Molecular Life Sciences : CMLS·Samiksha KukalRitushree Kukreti

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alternative splicing

Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.