Association of cadherin23 single nucleotide polymorphism with age-related hearing impairment in Han Chinese

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
Juen-Haur HwangTien-Chen Liu

Abstract

Genetic variation of cadheri23 (cdh23; 753G>A in exon 7) has been implicated with age-related hearing impairment (ARHI) in mice. This study aimed to test the association of the CDH23 tag single nucleotide polymorphism (SNP) in intron 7 with ARHI in Han Chinese. Individual cohort study. Tertiary medical center. A total of 1175 Han Chinese subjects were divided into the case group (n = 310, 26% with poorest hearing) and the control group (n = 308, the 26% with best hearing) according to the Z(high) score converted from the original frequency-specific hearing thresholds. The CDH23 SNP locus (rs7087735: C/T) in intron 7 (coordinate: 72996763) shown in the HapMap was genotyped with correlation to the hearing phenotype. The genotype distributions of CDH23 (CC/CT/TT) were not significantly different between the case and control group (P = .489). Compared with genotype CC, the odds ratios of the genotypes CT and TT for ARHI were not significantly different after adjustment for other environmental factors (P = .299 for CT; P = .610 for TT). Despite that the Ahl allele of Cdh23 had been implicated with ARHI in mice, we found no positive association of the CDH23 tag SNP in intron 7 with ARHI in Han Chinese.

References

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Apr 16, 2011·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Juen-Haur HwangTien-Chen Liu

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Citations

Sep 3, 2013·Geriatrics & Gerontology International·Qingwei RuanZhuowei Yu
Jan 31, 2013·Hearing Research·Erik C Böttger, Jochen Schacht
Aug 19, 2015·Frontiers in Cellular Neuroscience·Chao-Hui YangJochen Schacht
Aug 12, 2014·Metabolic Brain Disease·Juen-Haur HwangWei-Shiung Yang
Aug 23, 2018·Frontiers in Aging Neuroscience·Amal BouzidSaber Masmoudi

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Methods Mentioned

BETA
genotyping

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