Association of cancer stem cell markers genetic variants with gallbladder cancer susceptibility, prognosis, and survival

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Anu YadavBalraj Mittal

Abstract

Genes important to stem cell progression have been involved in the genetics and clinical outcome of cancers. We investigated germ line variants in cancer stem cell (CSC) genes to predict susceptibility and efficacy of chemoradiotherapy treatment in gallbladder cancer (GBC) patients. In this study, we assessed the effect of SNPs in CSC genes (surface markers CD44, ALCAM, EpCAM, CD133) and (molecular markers NANOG, SOX-2, LIN-28A, ALDH1A1, OCT-4) with GBC susceptibility and prognosis. Total 610 GBC patients and 250 controls were genotyped by using PCR-RFLP, ARMS-PCR, and TaqMan allelic discrimination assays. Chemotoxicity graded 2-4 in 200 patients and tumor response was recorded in 140 patients undergoing neoadjuvant chemotherapy (NACT). Differences in genotype and haplotype frequency distributions were calculated by binary logistic regression. Gene-gene interaction model was analyzed by generalized multifactor dimensionality reduction (GMDR). Overall survival was assessed by Kaplan-Meier survival curve and multivariate Cox-proportional methods. ALCAM Ars1157Crs10511244 (P = 0.0035) haplotype was significantly associated with GBC susceptibility. In GMDR analysis, ALCAM rs1157G>A, EpCAM rs1126497T>C emerged as best significant in...Continue Reading

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Citations

Dec 31, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Anu YadavBalraj Mittal
Aug 31, 2016·Journal of Gastrointestinal Cancer·Zahra ShahhoseiniSaeid Abediankenari
Jun 27, 2020·International Journal of Molecular Sciences·Chia-Ming YehMu-Kuan Chen
Mar 13, 2019·Journal of Cellular Biochemistry·Bifeng ChenXianhong Feng
Jun 28, 2017·World Journal of Gastroenterology : WJG·Aarti SharmaAshok Kumar
Aug 16, 2017·Indian Journal of Clinical Biochemistry : IJCB·Archana VermaRama Devi Mittal
Apr 26, 2020·Journal of Clinical Medicine·Dino BekricChristian Mayr

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