Association of cardiac autonomic neuropathy with arterial stiffness in type 2 diabetes mellitus patients.

Journal of Diabetes and Metabolic Disorders
Ataollah BagherzadehHossein Fakhrzadeh

Abstract

Diabetic patients are at the risk of cardiac autonomic neuropathy (CAN) and arterial stiffness. This study aimed to investigate the association of heart rate variability (HRV) as an index for CAN and pulse wave velocity (PWV) as an index for arterial stiffness. Uncomplicated diabetes type-2 patients who had no apparent history of cardiovascular condition underwent HRV and PWV measurements and the results were compared with the control group consisting of non-diabetic peers. Also, the findings were adjusted for the cardiovascular risk factors and other confounding factors. A total of 64 diabetic patients (age= 52.08±8.50 years; males=33 [51.6%]) were compared with 57 controls (age= 48.74±6.18 years; males=25 [43.9%]) in this study. Hypertension, dyslipidemia, and thereby systolic blood pressure and statin use were significantly more frequent in the diabetic group, while the serum levels of cholesterol, HDL-C and LDL-C were significantly higher in the controls. Pulse wave was significantly increased in the diabetic patients (p<0.001). Main HRV parameters were significantly lower in diabetics than in controls. After adjustment for the confounders, PWV and HRV remained significantly different between the groups (p=0.01 and p=0.004,...Continue Reading

References

Aug 1, 1991·Circulation·A MallianiS Cerutti
Apr 25, 2001·Circulation·M T La RovereUNKNOWN ATRAMI Investigators. Autonomic Tone and Reflexes After Myocardial Infarcton
Aug 4, 2001·Autonomic Neuroscience : Basic & Clinical·H V Huikuri, T H Mäkikallio
Aug 18, 2001·Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology·M V Pitzalis
Jun 24, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·C MeyerH J Teede
Apr 13, 2011·BMC Cardiovascular Disorders·Mori J KrantzEdward P Havranek
Aug 2, 2011·Experimental Diabetes Research·S LiatisN Tentolouris
Nov 15, 2011·Diabetes Research and Clinical Practice·David R WhitingJonathan Shaw
Jan 31, 2012·BMC Cardiovascular Disorders·Manuel Angel Gómez-MarcosUNKNOWN Vasorisk group

❮ Previous
Next ❯

Citations

Aug 22, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Yang YapeiCui Lianqun
Oct 27, 2018·Current Diabetes Reports·Vincenza Spallone
Oct 30, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Ahmet AvciBulent Behlul Altunkeser
Jul 28, 2016·Journal of Atherosclerosis and Thrombosis·Yusuke KobayashiSatoshi Umemura
Feb 26, 2016·Journal of Clinical Neuromuscular Disease·Ahmet Z Burakgazi, Soufian AlMahameed
Jun 3, 2017·Journal of Diabetes Research·Akihiko AndoShun Ishibashi

❮ Previous
Next ❯

Software Mentioned

HRV
SphygmoCor
SPSS

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.