Association of carotenoids with risk of gastric cancer: A meta-analysis

Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
Yunping ZhouShenyong Zhai

Abstract

Prior studies on carotenoids and gastric cancer risk have generated inconsistent results. We performed a meta-analysis of observational studies to summarize the evidence regarding the relation of carotenoids and gastric cancer risk. A comprehensive search was performed to identify all observational studies providing quantitative estimates between gastric cancer risk and carotenoids. The fixed or random effect model was selected based on the homogeneity test among studies in the highest vs. lowest categorical analyses. 13 published case-control studies with 14 results including 3919 cases and 7400 controls, and 8 cohort studies involving 1972 cases of gastric cancer and 96,691participants, met the inclusion criteria. For case-control studies, only intake of β-carotene and α-carotene were significantly associated with a reduced gastric cancer risk. The summary OR(95%CI) for β-carotene, α-carotene, lycopene and lutein were 0.52(0.46-0.59), 0.59(0.37-0.92), 0.88(0.55-1.41) and 0.85(0.56-1.30) respectively. In contrast, the summary RR(95%CI) for β-carotene, α-carotene, lycopene and lutein were 0.72(0.50-1.03), 0.79(0.58-1.07), 0.80(0.60-1.07) and 0.95(0.77-1.18), respectively. Although data from case-control studies suggested that β...Continue Reading

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Citations

Jun 23, 2016·Cancers·Raúl MartíJaime Cebolla-Cornejo
Apr 7, 2017·Journal of the Science of Food and Agriculture·Beatrice BergerSilke Ruppel
Jan 26, 2018·Critical Reviews in Food Science and Nutrition·Ranga Rao AmbatiSu Yuepeng
Mar 4, 2020·Annual Review of Food Science and Technology·Elvira Gonzalez de MejiaMary Ann Lila
Sep 11, 2019·Nutrition Reviews·David Benton, Hayley A Young
Sep 21, 2018·Nutrients·Silvio BuscemiGiulio Marchesini
Aug 28, 2021·World Journal of Clinical Cases·Qian-Hui ChenBing Chang

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