Association of CASP3 polymorphism with hematologic toxicity in patients with advanced non-small-cell lung carcinoma treated with platinum-based chemotherapy.

Cancer Science
Shaohua GuDaru Lu

Abstract

Apoptosis is a distinct mode of cell death that is responsible for the deletion of cells in tumors and in normal tissues. We pursued a pathway-based approach to investigate the association of potentially functional genetic polymorphisms of the corresponding genes with the outcomes of platinum-based chemotherapy in advanced non-small-cell lung cancer (NSCLC). A MALDI-TOF mass spectrometer was used for genotyping 10 polymorphisms of eight apoptosis-related genes, including BCL2 rs1801018, rs1564483, rs2279115, BAX rs4645878, caspase (CASP3) rs6948, CASP8 rs3834129, CASP10 rs13006529, rs3900115, tumor necrosis factor α (TNFα) rs1800629, and macrophage migration inhibitory factor (MIF) rs755622. The associations between these single nucleotide polymorphisms and the outcomes of 445 advanced NSCLC patients treated with platinum-based chemotherapy were evaluated. The CASP3 rs6948 polymorphism was most significantly associated with hematologic toxicity in a dose-dependent manner. The incidence of severe hematologic toxicity was significantly lower in C allele carriers (P = 0.005; odds ratio = 0.524; 95% confidence interval = 0.333-0.824) and still significant after a Bonferroni correction. The function of this single nucleotide polymor...Continue Reading

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Citations

Feb 16, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·J PengD R Lu
Apr 5, 2014·Journal of Pharmaceutical and Biomedical Analysis·Miguel Angel Merlos RodrigoRene Kizek
Feb 11, 2015·International Journal of Cardiology·Zhurong LuoMingfang Huang
Nov 22, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Yan-Qi HeWei-Min Li
May 23, 2019·Neurocritical Care·Leonardo LorenteVictor García-Marín
Jul 26, 2017·Environmental Health : a Global Access Science Source·Yinyin WuLei Yang
Jun 25, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Cheng-Di WangLiu-Shou Zhi

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