Association of CCR2-CCR5 haplotypes and CCL3L1 copy number with Kawasaki Disease, coronary artery lesions, and IVIG responses in Japanese children.

PloS One
Manju MamtaniJane C Burns

Abstract

The etiology of Kawasaki Disease (KD) is enigmatic, although an infectious cause is suspected. Polymorphisms in CC chemokine receptor 5 (CCR5) and/or its potent ligand CCL3L1 influence KD susceptibility in US, European and Korean populations. However, the influence of these variations on KD susceptibility, coronary artery lesions (CAL) and response to intravenous immunoglobulin (IVIG) in Japanese children, who have the highest incidence of KD, is unknown. We used unconditional logistic regression analyses to determine the associations of the copy number of the CCL3L1 gene-containing duplication and CCR2-CCR5 haplotypes in 133 Japanese KD cases [33 with CAL and 25 with resistance to IVIG] and 312 Japanese controls without a history of KD. We observed that the deviation from the population average of four CCL3L1 copies (i.e., <or>four copies) was associated with an increased risk of KD and IVIG resistance (adjusted odds ratio (OR)=2.25, p=0.004 and OR=6.26, p=0.089, respectively). Heterozygosity for the CCR5 HHF*2 haplotype was associated with a reduced risk of both IVIG resistance (OR=0.21, p=0.026) and CAL development (OR=0.44, p=0.071). The CCL3L1-CCR5 axis may play an important role in KD pathogenesis. In addition to clinical...Continue Reading

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Citations

Mar 28, 2013·Computational and Mathematical Methods in Medicine·Yu-wen LvHai-tao Lv
Nov 14, 2013·BMC Infectious Diseases·Eleni AklilluEdward J Hollox
Mar 28, 2012·Pediatric Cardiology·Hye-Eun KimUNKNOWN Korean Kawasaki Disease Genetics Consortium
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Jan 4, 2015·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Ho-Chang KuoWei-Chiao Chang
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Aug 21, 2019·Frontiers in Immunology·Marialbert Acosta-HerreraAna Márquez
Apr 8, 2020·Cardiovascular Therapeutics·Zhouping WangXiaoqiong Gu

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Methods Mentioned

BETA
genotyping

Software Mentioned

Stata
PowerMarker

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