Association of CD34 cell dose with hematopoietic recovery, infections, and other outcomes after HLA-identical sibling bone marrow transplantation.

Blood
H BittencourtEliane Gluckman

Abstract

Although CD34 cell dose is known to influence outcome of peripheral stem cell- and/or T-cell-depleted transplantation, such data on unmanipulated marrow transplantation are scarce. To study the influence of CD34(+) cell dose on hematopoietic reconstitution and incidence of infections after bone marrow transplantation, we retrospectively analyzed 212 patients from January 1994 to August 1999 who received a transplant of an unmanipulated graft from an HLA-identical sibling donor. Median age was 31 years; 176 patients had hematologic malignancies. Acute graft-versus-host disease prophylaxis consisted mainly in cyclosporin associated with methotrexate (n = 174). Median number of bone marrow nucleated cells and CD34(+) cells infused were 2.4 x 10(8)/kg and 3.7 x 10(6)/kg, respectively. A CD34(+) cell dose of 3 x 10(6)/kg or more significantly influenced neutrophil (hazard ratio [HR] = 1.37, P =.04), monocyte (HR = 1.47, P =.02), lymphocyte (HR = 1.70, P =.003), erythrocyte (HR = 1.77, P =.0002), and platelet (HR = 1.98, P =.00008) recoveries. CD34(+) cell dose also influenced the incidence of secondary neutropenia (HR = 0.60, P =.05). Bacterial and viral infections were not influenced by CD34 cell dose, whereas it influenced the inc...Continue Reading

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Citations

Mar 10, 2005·Journal of Clinical Laboratory Analysis·Roger S RileyJonathan M Ben-Ezra
Nov 19, 2004·Springer Seminars in Immunopathology·Eliane Gluckman, Vanderson Rocha
Mar 2, 2005·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Gameda BarendsePeter Jacobs
Nov 4, 2008·Bone Marrow Transplantation·L SillaR I Bittencourt
May 25, 2007·Stem Cells and Development·Pierre RolliniSerge Leyvraz
Jul 28, 2005·Blood·Steven Z PavleticUNKNOWN National Heart, Lung, and Blood Institute Unrelated Donor Marrow Transplantation Trial
Dec 3, 2014·Hematology/oncology Clinics of North America·Vikram MathewsMammen Chandy
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Mar 21, 2007·Bone Marrow Transplantation·A F CashenS M Devine
Apr 24, 2007·Best Practice & Research. Clinical Haematology·Alvaro Urbano-Ispizua
Apr 1, 2004·American Journal of Hematology·Patrick Huat-Chye TanThuan Chong Quah
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