Association of CD38 antigen expression with other prognostic parameters in early stages of chronic lymphocytic leukemia

Leukemia & Lymphoma
D HeintelU Jaeger

Abstract

The expression of the surface molecule CD38 on B cell chronic lymphocytic leukemia (B-CLL) cells has recently been described as a prognostic marker for patient survival. We have analyzed CD19/CD38 expression in 81 patients with predominantly early stages of B-CLL (69 Binet A, seven Binet B, five Binet C). Sixty-two patients (77%) had less than 30% CD38+/CD19+ cells, while 19 (23%) had > or = 30%. There was a significant association between Binet stages (A vs. B+C, p < 0.0001), Rai stages (0-II vs. III+IV, p < 0.001) and CD38 expression, confirming the published cut-off level of 30%. A particularly strong association between CD38 expression was found with soluble CD23 (sCD23) levels of > or = 2000 U/ml (p < 0.0001) and beta2-microglobulin (beta2 MG) serum levels of > or = 3 mg/l (p < 0.0001) indicating that CD38 is a marker of tumor mass as well as disease progression. A borderline association was found with lymphocyte doubling time (LDT) < 12 months (p = 0.05) due to low patient numbers, while there was no association with age, sex or immunoglobulin deficiency. Discordant results were obtained in a number of patients: 10 of 69 patients (14%) with Binet A had a CD38 > or = 30% while three of seven patients with Binet B had a CD3...Continue Reading

Citations

Dec 29, 2004·Leukemia & Lymphoma·J D SchwarzmeierM Shehata
May 27, 2004·Leukemia & Lymphoma·Tryfonia Mainou-FowlerGeoffrey P Summerfield
Apr 12, 2003·Leukemia & Lymphoma·Giovanni D'ArenaMichael J Keating
Jul 5, 2008·Blood Reviews·Femke Van BockstaeleJan Philippé
Jul 16, 2005·Hematology·Zoltan Matrai

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