Association of CD4+ T-lymphocyte counts and new thymic emigrants in HIV-infected children during successful highly active antiretroviral therapy.

The Journal of Allergy and Clinical Immunology
Akihiko SaitohStephen A Spector

Abstract

In a cohort of children receiving highly active antiretroviral therapy (HAART) with sustained plasma HIV-1 RNA < 50 copies/mL, children who reached undetectable RNA after week 8 (slow responders, median: week 20) had higher HIV-1 intracellular DNA (HIV-1 DNA) and equal or greater CD4+ T-lymphocyte counts compared with children who reached undetectable plasma HIV-1 RNA by week 8 (rapid responders) throughout HAART. To determine whether levels of T-cell receptor excision circles (TRECs) could explain the apparent inconsistency between the quantity of HIV-1 DNA and CD4+ T-lymphocyte counts in HIV-1-infected children receiving HAART with sustained virologic suppression. T-cell receptor excision circles and HIV-1 DNA and plasma HIV-1 RNA were quantified longitudinally by PCR in 31 children (median age, 5.6 years) with sustained undetectable plasma HIV-1 RNA for >104 weeks of HAART. There was a positive correlation between TREC and HIV-1 DNA during HAART, notably at weeks 48 and 80 (P < .004). During the early stage of HAART, TREC levels positively correlated with CD4+ T-lymphocyte percentages (P < .02) and naive CD4+ T-lymphocyte counts (P < .001) and percentages (P = .05). Median TREC levels were consistently equal or higher in slo...Continue Reading

Citations

Dec 22, 2007·AIDS·Raphael Ho Tsong FangChristel H Uittenbogaart
Feb 10, 2010·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Daniel Scott-AlgaraFlorence Buseyne
Nov 21, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Stéphane BlancheFlorence Buseyne
Jul 20, 2014·The Journal of Antimicrobial Chemotherapy·Charlotte BoulléVéronique Avettand-Fenoel
Feb 26, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ramia ZakhourGloria P Heresi
Jun 26, 2007·The Journal of Allergy and Clinical Immunology·Javier Chinen, William T Shearer
Feb 25, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Francesco SaglioFranca Fagioli
Oct 6, 2011·Current Opinion in Allergy and Clinical Immunology·Raz Somech
Oct 12, 2010·Clinical Microbiology Reviews·Sanjay RamPeter A Rice

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