PMID: 11902332Mar 21, 2002Paper

Association of CD40 ligand expression on HTLV-I-infected T cells and maturation of dendritic cells

Scandinavian Journal of Immunology
M MakinoM Baba

Abstract

Human T lymphotropic virus type I (HTLV-I) induces HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and adult T-cell leukemia (ATL). The development of HAM/TSP is associated with rapid maturation of dendritic cells (DCs), while ATL is accomplished with their maturation defect. The DC maturation is induced by cell-to-cell contact with CD4+ T cells expressing CD40 ligand (L). We determined the influence of CD40L expressed on various HTLV-I-infected T cells on the DC maturation. Around 60% of CD4+ T cells infected with HTLV-I for 1 week, expressed CD40L molecules involved in DC maturation. DCs matured by the CD40L+ T cells activated autologous CD4+ and CD8+ T cells. HTLV-I-immortalized T-cell lines established from healthy donors consistently expressed CD40L molecules for 3 months, however, some lines lost the expression soon thereafter. Interleukin (IL)-2-independent and transformed lines lacked that expression. Furthermore, T cells obtained from HAM/TSP patients expressed CD40L molecules for at least 3 weeks, whereas T cells from ATL patients did not express that. The CD40L T cells did not induce DC maturation, and required exogenous CD40L molecules for maturation. The CD40L+ T-cell-induced maturation was bloc...Continue Reading

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Citations

Nov 8, 2011·International Reviews of Immunology·Saifur RahmanPooja Jain
Feb 18, 2016·Pathogens and Disease·Chifu B HuangJeffrey L Ebersole
Jul 28, 2005·International Journal of Experimental Pathology·Gabriele PollaraDavid R Katz
Aug 2, 2017·Periodontology 2000·Jeffrey L EbersoleOctavio A Gonzalez
Apr 13, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Saifur RahmanPooja Jain
Dec 1, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Saifur RahmanPooja Jain

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