Association of CD8+ natural killer T cells in the liver with neonatal tolerance phenomenon

Transplantation
Hiroki KawamuraToru Abo

Abstract

Neonatal tolerance is a very interesting phenomenon, because even allogeneic skin grafts are not rejected in these mice at the adult stage. However, the underlying mechanism remains unclear. In this study we prepared such tolerant C57BL/6 (B6) mice (H-2b) by the injection of allogeneic lymphocytes of BALB/c origin (H-2d) at the neonatal stage. The total number of liver lymphocytes in these tolerant mice was found to increase when it was examined at the adult stage. Nevertheless, the retention of allogeneic lymphocytes that were injected at the neonatal stage was highest in the spleen. It is speculated that these allogeneic lymphocytes stimulate the hepatic immune system via the portal vein and that such stimulation maintains the tolerance phenomenon. Indeed, these tolerant mice showed elevated levels of IL-2R beta+ CD3int cells (i.e., extrathymic T cells) and NK1.1+ CD3int cells (i.e., NKT cells) in the liver. Even more interestingly, the number and proportion of CD8+ NKT cells, which are usually a minor population in normal mice, increased among NKT cells in the liver of tolerant mice. This became much more prominent when tolerant mice were grafted with allogeneic (H-2d) skin. In conjunction with additional data from a cell-tr...Continue Reading

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Citations

Jul 25, 2003·Human Immunology·Diana MetesNoriko Murase
May 19, 2007·Biomedical Research·Jiwei ShenToru Abo
Nov 17, 2007·Transplant Immunology·Miwa MoritaAtsushi Sugioka
Jul 6, 2005·European Journal of Immunology·Hiroki KawamuraToru Abo
Dec 4, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Ying LiKoichi Tanaka
Oct 16, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mark A Exley, Margaret James Koziel
Jun 17, 2014·Pediatric Transplantation·Seyed Kamran Hejazi KenariReza F Saidi
Apr 22, 2010·Drug Discovery Today. Disease Models·T L Van BelleM G von Herrath
Jun 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Takashi OnoeToshimasa Asahara

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