Association of CD8+ T-cells with bone erosion in patients with rheumatoid arthritis

International Journal of Rheumatic Diseases
Young Bin JooHye-Soon Lee

Abstract

Bone erosion is a major problem worsening quality of rheumatoid arthritis (RA) patients' lives. However, causal factors responsible for bone erosion in RA have remained unclear. We aimed to examine genetic variants conferring bone erosion in RA using a Korean genome-wide association study (GWAS) and to search for possible biological mechanisms underlying the development of bone erosion. We obtained genome-wide single nucleotide polymorphism (SNP) data for 711 Korean RA patients using Illumina HapMap 550v3/660W arrays. Associations between SNPs and bone erosion status based on the Steinbrocker staging system were examined using multivariate logistic regression. Cell-type-specific enrichment of the epigenomic chromatin annotation H3K4me3 at the bone erosion associated variants was further investigated using National Institute of Health Roadmap Epigenomics data. As we tested the associations between 439 289 SNPs and bone erosion in 385 patients with erosive RA and 326 with non-erosive RA, none of the tested SNPs reached the genome-wide significance threshold, although many loci showed modest genetic effect on bone erosion status with suggestive association (e.g., rs2741200 [P = 3.75 × 10-6 ] in the SLA-TG locus and rs12422918 [P =...Continue Reading

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Citations

Feb 28, 2019·Clinical Epigenetics·Roberta MazzoneAntonello Mai
Aug 18, 2017·Current Diabetes Reports·Samuel T JerramR David Leslie
Aug 4, 2021·Bone & Joint Research·Mengmeng DuanJing Xie

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