Association of central aortic pressures indexes with development of diabetes mellitus in essential hypertension

American Journal of Hypertension
Ju-Yi ChenJyh-Hong Chen

Abstract

Diabetes mellitus (DM) and hypertension (HT) frequently coexist. Increased central aortic pressures indexes are associated with HT; however, possible associations of these indexes with future development of DM have never been studied in HT. We recruited 178 patients with uncomplicated nondiabetic HT in this study. Baseline glucose, insulin, lipid profiles, and central aortic pressure indexes obtained using applanation tonometry were measured at the beginning of the study. Patients were followed for new-onset DM. After a mean follow-up period of 31 ± 12 months, 22 patients (12.4%) developed new-onset DM. In multivariate regression analyses adjusted for age, sex, and mean blood pressure (BP) in model 1, we found that central systolic BP (CSBP; hazard ratio 1.24, 95% CI 1.10-1.41, P < 0.001), and augmentation index (AIx) corrected at heart rate 75/min (AIx(75); hazard ratio 1.58, 95% CI 1.11-1.58, P < 0.05) were independent predictors for new-onset DM. After adjustment for age, sex, mean BP, glucose concentration, and β-blocker use in model 2, we found that CSBP (hazard ratio 1.36, 95% CI 1.19-1.55, P < 0.001) and AIx(75) (hazard ratio 1.71, 95% CI 1.16-2.52, P < 0.01) were independent predictors for new-onset DM. CSBP and AIx(75)...Continue Reading

References

Mar 1, 2003·Diabetes Care·Jaana Lindström, Jaakko Tuomilehto
Apr 16, 2003·Circulation·Ronald M A HenryUNKNOWN Hoorn Study
May 15, 2003·JAMA : the Journal of the American Medical Association·Katharina Wolf-MaierFenicia Vescio
Jan 13, 2004·Journal of the American College of Cardiology·Gérard M LondonUNKNOWN REASON Project Investigators
Dec 7, 2005·Journal of Hypertension·Giuseppe ManciaAlberto Zanchetti
Jan 3, 2006·Current Hypertension Reports·Susan Simmons Holcomb
Jul 29, 2006·Diabetes Care·Wichai AekplakornRajata Rajatanavin
Feb 28, 2007·American Journal of Hypertension·Marie McNultyJohn Feely
Jul 12, 2007·Annals of Nutrition & Metabolism·Abbas Ali Mansour, Meelad Imad Al-Jazairi

❮ Previous
Next ❯

Citations

Jun 6, 2012·International Journal of Vascular Medicine·Lee StonerSimon Fryer
Sep 21, 2010·American Journal of Hypertension·Thomas Weber
Jan 10, 2012·American Journal of Hypertension·Rachel E D ClimieJames E Sharman
Oct 4, 2017·Diabetes Care·Iram Faqir MuhammadGunnar Engström
Sep 29, 2020·Circulation Research·Mengyi ZhengShouling Wu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.