Association of cerebral white matter lesions with cognitive function and mood in Japanese elderly people: a population-based study

Brain and Behavior
Mika YamawakiKenji Nakashima

Abstract

To determine the relationships between regional white matter lesions (WMLs), lifestyle factors, and cognitive, motor function and mood. A comprehensive evaluation, including brain MRI, blood tests, the Unified Parkinson's Disease Rating Scale, the Mini Mental State Examination, and the Geriatric Depression Scale, was performed for people aged 65 years or older living in Ama-cho on October 1, 2009. Participants were classified by severity of periventricular hyperintensities (PVH) and deep white matter hyperintensities (DWMH) using the Fazekas score. Of 900 eligible participants, 688 (76.4%) were enrolled, including 303 men. Significant predictors of severe PVH were older age, lower low-density lipoprotein cholesterol (LDL-C) levels, elevated blood pressure (BP), cerebral infarction, and no current alcohol use. Significant predictors of severe DWMH were older age, lower 1,5-anhydroglucitol (1,5-AG) levels, elevated BP, cerebral infarction, and no current alcohol use. Higher cognitive function was associated with younger age, female sex, mild DWMH, more years of education, and higher high-density lipoprotein cholesterol levels. Depressive symptoms were associated with lower 1,5-AG levels, lower LDL-C levels, moderate to severe PVH...Continue Reading

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Citations

Mar 6, 2016·Journal of the Neurological Sciences·Kenji Wada-IsoeKenji Nakashima
Dec 4, 2019·Journal of the International Neuropsychological Society : JINS·Astrid Suchy-DiceySteven P Verney
Nov 9, 2017·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Y ChenM Lou
Feb 23, 2020·Frontiers in Neurology·Sanskriti Sasikumar, Antonio P Strafella
Mar 11, 2020·International Journal of Environmental Research and Public Health·Minako HadaTakaaki Tomofuji
Mar 25, 2019·Dementia and Neurocognitive Disorders·Bora YoonSoo Jin Yoon
Mar 12, 2020·Yonago Acta Medica·Masafumi KishiKenji Nakashima
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Nov 16, 2021·Frontiers in Neurology·Lorena Jiménez-SánchezJoanna M Wardlaw

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