Association of chemically induced forestomach cell proliferation and carcinogenesis

Cancer Letters
B I GhanayemH B Matthews

Abstract

A number of chemicals have been shown to cause malignant neoplasms in the forestomach of Fischer 344 rats when administered chronically by gavage. The present study was designed to identify early forestomach lesions following 2-week repeated gavage administration of some of these forestomach carcinogens. In this manner, we attempted to examine the hypothesis that early cell proliferation is associated with repetitive gavage administration of these chemicals. Groups of 8 or more male F344 rats received 1 of 6 reported forestomach carcinogens (ethyl acrylate (EtAc), diglycidyl resorcinol ether(DGRE), 1,2-dibromoethane (DBE), 1,2-dibromo-3-chloro-propane (DBCP), 1-chloro-2-methylpropene (dimethylvinyl chloride, DMVC) and 3-chloro-2-methylpropene (CMP)), 1 of 2 structurally related chemicals (methyl methacrylate (MMA) and dichloroethane (DCE)) which were negative in chronic carcinogenicity studies or the vehicle (corn oil) alone 5 days/week for 2 weeks. Histopathologic examination of forestomachs of rats killed 24 h after the last dose indicated no significant difference in the incidence or severity of epithelial cell proliferation in the rat forestomach between the vehicle control group and the 2 negative control groups. In contra...Continue Reading

Citations

Dec 1, 1990·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G M WilliamsM J Iatropoulos
Oct 1, 1990·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A S MurthyA E Good
Feb 1, 1991·Toxicology Letters·B I GhanayemH B Matthews
Sep 1, 1992·Toxicology Letters·D W Potter, T B Tran
Mar 1, 1989·The American Journal of Pathology·T M MonticelloJ A Popp
Dec 1, 1993·Environmental Health Perspectives·B I GhanayemH B Matthews
Dec 21, 2006·Journal of Occupational Health·Kasuke NaganoTaijiro Matsushima
Jun 1, 1989·Regulatory Toxicology and Pharmacology : RTP·B E Butterworth
Jun 21, 2008·Risk Analysis : an Official Publication of the Society for Risk Analysis·Kenneth T Bogen
Jul 8, 2011·Toxicologic Pathology·Jeff S McKee, Jerome H Gass
Jan 1, 1988·Toxicologic Pathology·P W Wester, R Kroes

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