Association of Chemotherapy Timing in Pregnancy With Congenital Malformation.

JAMA Network Open
Mathilde van GerwenInternational Network on Cancer, Infertility and Pregnancy

Abstract

Chemotherapy during the first trimester of pregnancy should be avoided owing to the risk of congenital malformations. However, the precise gestational age at which chemotherapy can be initiated safely remains unclear. To assess congenital malformation rates associated with gestational age at initiation of chemotherapy among pregnant women with cancer. This multicenter cohort study evaluated all pregnant women who received chemotherapy between 1977 and 2019 registered in the International Network on Cancer, Infertility and Pregnancy (INCIP) database. Data were analyzed from February 15 to June 2, 2020. Cancer treatment with chemotherapy during pregnancy. Analysis was focused on major and minor structural malformations in offspring, defined by EUROCAT, detected during pregnancy or at birth. A total of 755 women in the INCIP database who underwent cancer treatment with chemotherapy during pregnancy were included in analysis. The median (range) age at cancer diagnosis was 33 (14-48) years. Among offspring, the major congenital malformation rate was 3.6% (95% CI, 2.4%-5.2%), and the minor congenital malformation rate was 1.9% (95% CI, 1.0%-3.1%). Chemotherapy exposure prior to 12 weeks gestational age was associated with a high rate...Continue Reading

References

May 4, 2004·The Lancet Oncology·Elyce Cardonick, Audrey Iacobucci
Jun 19, 2009·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Frédéric AmantAndreas du Bois
Jul 28, 2010·Journal of Medical Screening·Ester GarneUNKNOWN EUROCAT
Sep 26, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marie E WoodLois B Travis
Sep 29, 2015·The New England Journal of Medicine·Frédéric AmantUNKNOWN International Network on Cancer, Infertility, and Pregnancy (INCIP)
Jun 8, 2017·Pediatric Hematology and Oncology·Eva ClemensMarry M van den Heuvel-Eibrink
Jan 13, 2018·ESMO Open·Margaret C Cupit-LinkShahrukh K Hashmi
Jan 1, 2019·Journal of the American Heart Association·E A M Lieke FeijenUNKNOWN DCOG‐LATER Study Group

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Software Mentioned

SPSS Statistics
EUROCAT
INCIP

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