Association of Chemotherapy With Survival in Elderly Patients With Multiple Comorbidities and Estrogen Receptor-Positive, Node-Positive Breast Cancer.

JAMA Oncology
Nina TamirisaIsabelle Bedrosian

Abstract

Breast cancer risk and comorbidities increase with age. Data are lacking on the association of adjuvant chemotherapy with survival in elderly patients with multiple comorbidities and node-positive breast cancer. To examine the association of chemotherapy with survival in elderly patients with multiple comorbidities and estrogen receptor-positive, node-positive breast cancer. This retrospective cohort study included patients in the US National Cancer Database who were 70 years or older; had a Charlson/Deyo comorbidity score of 2 or 3; had estrogen receptor-positive, ERBB2 (formerly HER2 or HER2/neu)-negative breast cancer; and underwent surgery for pathologic node-positive breast cancer from January 1, 2010, to December 31, 2014. Propensity scores were used to match patients receiving adjuvant chemotherapy with those not receiving adjuvant chemotherapy based on age, comorbidity score, facility type, facility location, pathologic T and N stage, and receipt of adjuvant endocrine and radiation therapy. Data analysis was performed from December 13, 2018, to April 28, 2020. Chemotherapy. The association of adjuvant chemotherapy with overall survival was estimated using a double robust Cox proportional hazards regression model. Of a t...Continue Reading

References

Mar 17, 2001·JAMA : the Journal of the American Medical Association·R YancikJ W Yates
Feb 24, 2001·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N K IbrahimG N Hortobagyi
Sep 2, 2004·Journal of the National Cancer Institute·Catherine SchairerSusan S Devesa
Feb 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sharon H GiordanoMelissa L Bondy
Mar 3, 2005·JAMA : the Journal of the American Medical Association·Hyman B MussUNKNOWN Cancer and Leukemia Group B
Jun 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sharon H GiordanoJames S Goodwin
Jun 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elena B ElkinKatherine S Panageas
Sep 28, 2006·Breast Cancer Research and Treatment·Cynthia OwusuRebecca A Silliman
Aug 21, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hyman B MussUNKNOWN Cancer and Leukemia Group B Experience
Sep 17, 2009·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Naruto TairaYasuo Ohashi
May 25, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jacquie H ChirgwinBeat Thürlimann
Jun 29, 2016·Journal of Cancer Research and Clinical Oncology·C W WallwienerB Krämer
Aug 11, 2017·British Journal of Cancer·D O OkonjiA Ring
May 22, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Supriya G MohileArti Hurria
Jun 13, 2018·Journal of the National Comprehensive Cancer Network : JNCCN·Traci LeMastersDustin Long

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Citations

Jun 28, 2021·Breast Cancer Research and Treatment·Jeffrey E JohnsonStephanie Downs-Canner
Jul 23, 2021·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Akimitsu YamadaMasataka Sawaki
Jun 30, 2021·Current Opinion in Oncology·Nicolò Matteo Luca Battisti, Laura Biganzoli

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