Association of childhood cancer with residential traffic density.

Scandinavian Journal of Work, Environment & Health
D A Savitz, L Feingold

Abstract

Data from a recently completed case-referent study of childhood cancer were used to explore a possible role of environmental exposures from traffic exhaust. The street addresses of 328 cancer patients and 262 population-based referents were used to assign traffic density (vehicles per day) as a marker of potential exposure to motor vehicle exhaust. An odds ratio of 1.7 [95% confidence interval (95% CI) 1.0-2.8] was found for the total number of childhood cancers and 2.1 (95% CI 1.1-4.0) for leukemias in a contrast of high and low traffic density addresses (greater than or equal to 500 versus less than 500 vehicles per day). Stronger associations were found with a traffic density cutoff score of greater than or equal to 10,000 vehicles per day, with imprecise odds ratios of 3.1 (95% CI 1.2-8.0) and 4.7 (95% CI 1.6-13.5) for the total number of cancers and leukemias, respectively. Adjustment for suspected risk factors for childhood cancer did not substantially change these results. Though the results are inconclusive, the identified association warrants further evaluation.

Citations

Jan 1, 1993·Bioelectromagnetics·T DovanD A Savitz
Aug 18, 2009·Cancer Causes & Control : CCC·Roberta McKean-CowdinSusan Preston-Martin
Jul 8, 2010·Cancer Causes & Control : CCC·Elvira Vaclavik BräunerOle Raaschou-Nielsen
Oct 28, 1996·The Science of the Total Environment·O Raaschou-NielsenC Lohse
Nov 20, 2001·The Science of the Total Environment·J RankP H Jespersen
Jul 1, 1995·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·G G Giles
Oct 16, 2002·Annals of Epidemiology·Bryan LangholzStephanie J London
Jun 6, 2009·Journal of Exposure Science & Environmental Epidemiology·Thomas SchettgenThomas Kraus
May 13, 2008·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Donald T WigleDaniel Krewski
Apr 1, 1995·Risk Analysis : an Official Publication of the Society for Risk Analysis·M A MillerA J Ruttenber
Dec 14, 1991·BMJ : British Medical Journal·F Godlee
Feb 28, 2013·BMJ Open·Susanna LagorioCorrado Magnani
Aug 16, 2005·Journal of Epidemiology and Community Health·E G Knox
Jan 18, 2006·Journal of Epidemiology and Community Health·E G Knox
Nov 25, 2003·Occupational and Environmental Medicine·P A McKinneyUNKNOWN UK Childhood Cancer Study Investigators
Sep 5, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Julie Von BehrenPatricia A Buffler
May 5, 2009·International Journal of Health Geographics·Brian G FrizzelleBarbara A Laraia
Dec 18, 2001·Environmental Health Perspectives·I C AhlbomUNKNOWN ICNIRP (International Commission for Non-Ionizing Radiation Protection) Standing Committee on Epidemiology
Dec 15, 2010·Environmental Health Perspectives·Alicia AmigouJacqueline Clavel
Sep 12, 2013·Environmental Health Perspectives·Julia E HeckBeate Ritz
Apr 5, 2003·Environmental Health Perspectives·Peggy ReynoldsDaniel F Smith
Dec 31, 2003·Environmental Health Perspectives·Rochelle S GreenBart Ostro
Sep 1, 1995·Environmental Health Perspectives·S H Zahm, S S Devesa
Sep 7, 2007·Environmental Health Perspectives·Paul A Zandbergen, Joseph W Green
Sep 25, 1997·Environmental Health Perspectives·O Raaschou-NielsenJ H Olsen
Jul 1, 1991·Cancer Causes & Control : CCC·C Poole, D Trichopoulos
Jul 13, 2004·International Journal of Radiation Biology·P R JamesD L Henshaw
Jan 1, 1996·International Journal of Radiation Biology·D L HenshawA W Preece
Oct 14, 2010·Critical Reviews in Toxicology·David GalbraithDennis Paustenbach
Mar 22, 2014·American Journal of Preventive Medicine·Vickie L BootheFuyuen Y Yip
Sep 18, 2015·American Journal of Epidemiology·Jennifer HouotJacqueline Clavel
Nov 2, 2015·European Journal of Epidemiology·Ben D SpycherClaudia E Kuehni
Jan 14, 2010·Chemico-biological Interactions·David Pyatt, Sean Hays

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Scandinavian Journal of Work, Environment & Health
M FeychtingA Ahlbom
American Journal of Epidemiology
O Raaschou-NielsenJ H Olsen
International Journal of Cancer. Journal International Du Cancer
Paolo CrosignaniFranco Berrino
© 2022 Meta ULC. All rights reserved