Association of Childhood Lead Exposure With MRI Measurements of Structural Brain Integrity in Midlife.

JAMA : the Journal of the American Medical Association
Aaron ReubenTerrie E Moffitt

Abstract

Childhood lead exposure has been linked to disrupted brain development, but long-term consequences for structural brain integrity are unknown. To test the hypothesis that childhood lead exposure is associated with magnetic resonance imaging (MRI) measurements of lower structural integrity of the brain in midlife. The Dunedin Study followed a population-representative 1972-1973 birth cohort in New Zealand (N = 564 analytic sample) to age 45 years (until April 2019). Childhood blood lead levels measured at age 11 years. Structural brain integrity at age 45 years assessed via MRI (primary outcomes): gray matter (cortical thickness, surface area, hippocampal volume), white matter (white matter hyperintensities, fractional anisotropy [theoretical range, 0 {diffusion is perfectly isotropic} to 100 {diffusion is perfectly anisotropic}]), and the Brain Age Gap Estimation (BrainAGE), a composite index of the gap between chronological age and a machine learning algorithm-estimated brain age (0 indicates a brain age equivalent to chronological age; positive and negative values represent an older and younger brain age, respectively). Cognitive function at age 45 years was assessed objectively via the Wechsler Adult Intelligence Scale IV (I...Continue Reading

References

Dec 13, 2002·Brain : a Journal of Neurology·Theodore I Lidsky, Jay S Schneider
Apr 1, 2004·Cerebral Cortex·David H SalatBruce Fischl
Mar 19, 2005·Brain : a Journal of Neurology·Hélène AmievaJean-François Dartigues
Jul 9, 2005·Environmental Health Perspectives·Bruce P LanphearRussell Roberts
Jan 9, 2008·Environmental Health : a Global Access Science Source·Nick Wilson, John Horrocks
Mar 12, 2008·Current Opinion in Pediatrics·David C Bellinger
May 30, 2008·PLoS Medicine·Kim M CecilBruce P Lanphear
Jun 17, 2009·Journal of Occupational and Environmental Medicine·Huiling NieHoward Hu
Apr 9, 2010·Brain : a Journal of Neurology·Tom den HeijerMonique M B Breteler
Mar 16, 2011·Archives of Neurology·Robert S WilsonDavid A Bennett
Apr 5, 2014·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Richard A Armstrong
Feb 18, 2015·Nature Reviews. Neurology·Niels D Prins, Philip Scheltens
Apr 4, 2015·Social Psychiatry and Psychiatric Epidemiology·Richie PoultonPhil A Silva
Feb 26, 2016·Brain : a Journal of Neurology·Mohamad HabesChristos Davatzikos
Jul 20, 2016·Proceedings of the National Academy of Sciences of the United States of America·Kristine B WalhovdAnders M Fjell
Oct 4, 2016·Frontiers in Human Neuroscience·Tomoyo MoritaEiichi Naito
Nov 29, 2016·NeuroImage·Franziskus LiemDaniel S Margulies
Oct 28, 2017·Trends in Neurosciences·James H Cole, Katja Franke
Jun 28, 2018·Annual Review of Psychology·Lars Nyberg, Sara Pudas
Jan 15, 2020·Nature Medicine·Andrew T MarshallElizabeth R Sowell
Jan 15, 2020·Nature Medicine·Aaron ReubenAvshalom Caspi
Jan 22, 2020·Nature Human Behaviour·Leah S Richmond-RakerdTerrie E Moffitt

❮ Previous
Next ❯

Citations

May 26, 2021·The Science of the Total Environment·Joseph BoyleDavid C Wheeler
Nov 4, 2021·Journal of Exposure Science & Environmental Epidemiology·Clara G SearsJoseph M Braun

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.