Association of childhood stress with late-life dementia and Alzheimer's disease: the KIHD study

European Journal of Public Health
Gwendolyn A R DonleyJ Kauhanen

Abstract

There remains a dearth of life-course studies analyzing childhood environment and late-life chronic illness. In particular, few have addressed possible early-life predictors of dementia. This study examines relationships between childhood stress and later-age dementia, specifically Alzheimer's disease (AD). We used data from 2682 men in the population-based Kuopio Ischemic Heart Disease Risk Factor Study who participated in extensive baseline health examinations and interviews between 1984 and 1989, when they were between 42 and 61 years of age. Childhood events were documented in these structured interviews. We created a composite childhood stress variable that included living in custody or an orphanage, experience of crisis in childhood, having problems with teachers and emigrating because of war. Data on incident cases of dementia, including AD, were obtained through 2014 via national health register linkages. Risk of developing dementia was estimated using Cox regression adjusting for age, education, income and prior/existing diseases at baseline. Childhood stress was associated with increased risk of dementia (HR = 1.86, 95% CI: 1.12-3.10). Associations remained statistically significant after adjustment for age, education...Continue Reading

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Citations

Apr 10, 2020·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Mozhu DingLaura Fratiglioni
Mar 7, 2019·Frontiers in Cellular Neuroscience·Duraisamy KempurajAsgar Zaheer
Mar 22, 2020·Journal of Neuroinflammation·Maralinde R AbbinkAniko Korosi
Aug 18, 2020·Reviews in the Neurosciences·Yi Ko, Soi Moi Chye
Dec 29, 2020·Journal of Psychiatric Research·Galit WeinsteinDavid Tanne
Dec 17, 2020·European Journal of Epidemiology·Sander LamballaisMohammad Arfan Ikram
Jan 23, 2021·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Mark D HaywardEileen M Crimmins
Jun 22, 2021·Journal of Alzheimer's Disease : JAD·Pamela HerdSanjay Asthana
Jun 24, 2021·Biological Reviews of the Cambridge Philosophical Society·Ayeisha Milligan ArmstrongDavid Groth
Jul 7, 2021·Biochemistry. Biokhimii︠a︡·Leonid G Khaspekov

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