Association of Chlamydia trachomatis, C. pneumoniae , and IL-6 and IL-8 Gene Alterations With Heart Diseases

Frontiers in Immunology
Núbia Caroline C AlmeidaR Ishak

Abstract

Atherosclerosis is a progressive disease characterized by chronic inflammation of the arterial walls, associated with genetic and infectious factors. The present study investigated the involvement of Chlamydia trachomatis and Chlamydia pneumoniae infections and immunological markers (C-reactive protein, CRP, TNF-α, IL-6, IL-8, and IL-10) in the process of atherosclerosis. The evaluation included 159 patients for surgical revascularization (CAD) and 71 patients for surgical heart valve disease (HVD) at three hospitals in Belém, Brazil. The control group (CG) comprised 300 healthy individuals. Blood samples collected before surgery were used for antibodies detection (enzyme immunoassay), CRP (immunoturbidimetry) and IL-6 levels (enzyme immunoassay). Tissue fragments (atheroma plaque, heart valve and ascending aorta) were collected during surgery and subjected to qPCR for detection of bacterial DNA. Promoter region polymorphisms of each marker and relative quantification of TNF-α, IL-8, and IL-10 gene expression were performed. Demography and social information were similar to the general population involved with both diseases. Antibody prevalence to C. trachomatis was 30.6, 20.3, and 36.7% (in the CAD, HVD, and CG, respectively) ...Continue Reading

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Citations

Jun 8, 2021·Frontiers in Immunology·Wenjing XiangZhou Zhou
Oct 2, 2021·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Himanshu RaiRobert A Byrne

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
DNA Assay
electrophoresis
PCR
Genotyping
ELISA

Software Mentioned

Primer3
Access
GraphPad Prism
FastPCR
BioEstat

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