Association of CHRNA5 Gene Variants with Crack Cocaine Addiction.

Neuromolecular Medicine
Angelita P ArocheJaqueline B Schuch

Abstract

Genome-wide studies provide increasing evidence of association of genetic variants with different behaviors. However, there is a growing need for replication and subsequent characterization of specific findings. In this sense, the CHRNA5 gene has been associated with nicotine (with genome-wide significance), alcohol and cocaine addictions. So far, this gene has not been evaluated in smoked (crack) cocaine. We aimed to analyze the influence of CHRNA5 variants in crack addiction susceptibility and severity. The sample includes 300 crack-addicted patients and 769 non-addicted individuals. The CHRNA5 SNPs evaluated were rs588765, rs16969968, and rs514743. Homozygosity for rs16969968 and rs588765 major alleles was nominally associated with a risk to crack addiction (GG, P = 0.032; CC, P = 0.036, respectively). Haplotype analyses reveal significant associations (rs588765|rs16969968|rs514743 pglobal-corrected = 7.66 × 10-5) and suggest a substantial role for rs16969968. These findings corroborate previous reports in cocaine addiction-in line with the expected effects of cocaine in the cholinergic system-and in the opposite direction of significant GWAS findings for nicotine addiction susceptibility. These results are strengthened by t...Continue Reading

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Citations

Jan 30, 2021·Arab Journal of Basic and Applied Sciences·Thaka'a K Al-OmoushThomas Eissenberg
Aug 29, 2021·Molecular Psychiatry·Noèlia Fernàndez-CastilloBru Cormand

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Methods Mentioned

BETA
genotyping

Software Mentioned

Statistical Package for the Social Sciences ( SPSS )
PLINK
PROVEAN
HaploReg
SIFT
RegulomeDB
GTEx
Polyphen

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