Association of Chronic Kidney Disease With Small Vessel Disease in Patients With Hypertensive Intracerebral Hemorrhage

Frontiers in Neurology
Yuan-Hsiung TsaiMing-Hsueh Lee

Abstract

Chronic kidney disease (CKD) has been closely associated with hypertension and stroke. Although studies have reported the relationship between CKD and cerebral small vessel disease (SVD), the link between CKD, hypertension, and SVD is uncertain. The aim of this study was to investigate the association between CKD and SVD in patients with strictly hypertensive intracerebral hemorrhage (ICH). 142 patients with acute hypertensive ICH were enrolled in this study. Magnetic resonance imaging was performed to assess imaging markers for SVD. Patients were categorized into three CKD groups based on the degree of kidney dysfunction [glomerular filtration rate (GFR) in milliliters per minute per 1.73 m2]: normal kidney function (GFR ≥ 90), mild kidney disease (60 ≤ GFR < 90), and moderate to severe kidney disease (GFR < 60). The prevalence rate of mild and moderate to severe CKD was 50 and 14.8%, respectively. The stage of CKD was associated with history of chronic hypertension (p = 0.046) as well as the prevalence rate of overall and deep cerebral microbleed (CMB) (p = 0.001 and p = 0.002, respectively). The stage of CKD was a significant risk factor for deep white matter hyperintensity (WMH) (OR 1.848; 95% CI 1.022-3.343, p = 0.042), ov...Continue Reading

References

Dec 18, 1968·Acta Neuropathologica·C M Fisher
Dec 1, 1967·Brain : a Journal of Neurology·F M Cole, P Yates
Sep 1, 1994·The Journal of Pediatrics·A R HohnJ H Dwyer
May 11, 2001·The New England Journal of Medicine·A I QureshiD F Hanley
Jul 31, 2002·Brain Pathology·G Alistair Lammie
Dec 5, 2006·Journal of Hypertension·Alexandra L C MartiniukUNKNOWN Asia-Pacific Cohort Studies Collaboration
Oct 27, 2007·Stroke; a Journal of Cerebral Circulation·Minesh KhatriCharles DeCarli
Nov 21, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·J Y AhnJ W Lee
Dec 1, 2007·Stroke; a Journal of Cerebral Circulation·M Arfan IkramMonique M B Breteler
Feb 3, 2009·Stroke; a Journal of Cerebral Circulation·Gilad YahalomDavid Tanne
Mar 6, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Sadayoshi ItoTakefumi Mori
Dec 29, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hideaki ShimaYoshiki Nishizawa
Oct 5, 2010·BMJ : British Medical Journal·Meng LeeBruce Ovbiagele
Oct 12, 2010·Journal of Neurology, Neurosurgery, and Psychiatry·Alida A GouwJeroen J G Geurts
Jan 25, 2011·Journal of Neuroradiology. Journal De Neuroradiologie·Y-H TsaiH-F Wong
Apr 23, 2013·Lancet Neurology·Joanna M WardlawMartin Dichgans
Jul 13, 2013·Stroke; a Journal of Cerebral Circulation·Bruce OvbiageleChelsea S Kidwell
Jul 23, 2013·Lancet Neurology·Joanna M WardlawUNKNOWN STandards for ReportIng Vascular changes on nEuroimaging (STRIVE v1)
Oct 16, 2014·Lancet Neurology·Kazunori Toyoda, UNKNOWN all authors
Dec 3, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Tetsuya MiyagiKazunori Toyoda
Dec 17, 2014·American Journal of Hypertension·Jin-biao ZhangXiao-hua Jü
Dec 31, 2014·Cerebrovascular Diseases·Stephen D J MakinJoanna M Wardlaw
Feb 19, 2015·Journal of Stroke·Kazunori Toyoda
Apr 16, 2015·Cerebrovascular Diseases Extra·Genya ToyodaShuhei Yamaguchi
Jan 15, 2016·International Journal of Stroke : Official Journal of the International Stroke Society·Andreas CharidimouSeth Love
Feb 6, 2016·Stroke; a Journal of Cerebral Circulation·Shoichiro SatoUNKNOWN INTERACT2 Investigators
Mar 8, 2016·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Danni ZhengUNKNOWN INTERACT2 Investigators

❮ Previous
Next ❯

Citations

Sep 27, 2020·The European Journal of Neuroscience·Birva ShahPallab Bhattacharya

❮ Previous
Next ❯

Methods Mentioned

BETA
sedation

Software Mentioned

Statistical Program for Social Sciences ( SPSS )

Related Concepts

Related Feeds

Basal Ganglia Cerebrovascular Disease

Basal ganglia cerebrovascular disease is a condition where the blood vessels in the basal ganglia are damaged or malfunction. Discover the latest research on basal ganglia cerebrovascular disease here.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.