Association of chronic kidney disease with outcomes in chronic heart failure: a propensity-matched study.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Ruth C CampbellAli Ahmed

Abstract

Chronic kidney disease (CKD) is associated with increased mortality in patients with heart failure (HF). However, its association with hospitalization in HF patients has not been well studied. Of 7788 patients in the Digitalis Investigation Group trial, 3527 had CKD, defined by an estimated glomerular filtration rate (GFR) <60 ml/min/1.73 m(2) body surface area (BSA). Propensity scores for CKD were calculated using a multivariable logistic regression model and used to match 2399 pairs of patients with and without CKD. Matched Cox regression analyses were used to estimate association of CKD with outcomes. All-cause hospitalization occurred in 1636 (rate, 4233/10,000 person-years) and 1587 (rate, 3733/10,000 person-years) patients respectively, with and without CKD (matched hazard ratio [HR] for CKD, 1.18, 95% confidence interval [CI], 1.08-1.29; P < 0.0001). Matched HR for cardiovascular and HF hospitalization were respectively 1.17 (95% CI, 1.06-1.28, P = 0.002) and 1.28 (95% CI, 1.13-1.45, P < 0.0001). Compared to GFR >or=60 ml/min/1.73 m(2) BSA, HR for all-cause hospitalization for GFR 45-59 and <45 ml/min/1.73 m(2) BSA were respectively 1.04 (95% CI, 0.94-1.16; P = 0.422) and 1.58 (95% CI, 1.34-1.87; P < 0.0001). Similarly, ...Continue Reading

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Citations

Feb 27, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sean M BagshawUNKNOWN Acute Dialysis Quality Initiative Consensus Group
Jan 15, 2011·International Journal of Nephrology·Dinna N Cruz, Sean M Bagshaw
Sep 2, 2008·Heart Failure Clinics·Ali Ahmed, Ruth C Campbell
Dec 17, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Rosita ZakeriS Jeson Sangaralingham
Aug 16, 2015·Therapeutic Advances in Cardiovascular Disease·Evelyn Mendoza-TorresMaría Paz Ocaranza
Feb 23, 2018·American Journal of Nephrology·Laurent BitkerLaurent Juillard
Oct 16, 2010·Pacing and Clinical Electrophysiology : PACE·Yu-Lan JouShih-Ann Chen
Apr 28, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Richard HaynesColin Baigent
Feb 28, 2020·The Cochrane Database of Systematic Reviews·Meaghan LunneyPietro Ravani
Sep 29, 2017·Korean Circulation Journal·Min-Seok KimDong-Ju Choi
Jan 5, 2011·Heart Failure Reviews·Dinna N CruzSean M Bagshaw
Nov 26, 2015·Terapevticheskiĭ arkhiv·B G Iskenderov, O N Sisina
May 21, 2010·European Journal of Heart Failure·Kathy HebertLee M Arcement
Oct 16, 2012·Journal of the American College of Cardiology·Larry A WeinrauchJohn A D'Elia
Aug 28, 2021·Journal of Personalized Medicine·Ling LinHildo J Lamb
Sep 20, 2011·International Journal of Cardiology·Shanmugakumar ChinnappaLip-Bun Tan

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