PMID: 15374168Jul 1, 1996Paper

Association of chronic non-steroidal anti-inflammatory drugs use and cognitive decline in non-demented elderly patients admitted to a geriatric evaluation and rehabilitation unit

Archives of Gerontology and Geriatrics
B BertozziM Trabucchi

Abstract

In a geriatric evaluation and rehabilitation unit (GERU), 258 elderly patients (M: 71, F: 187; mean age 77.4 +/- 7.5) scoring 22 or more at Mini-Mental State Examination (MMSE) consecutively admitted were assessed in order to evaluate the effects of non-steroidal anti-inflammatory drugs (NSAID) chronic treatment on cognitive status in non-demented elderly patients. Sixty-six patients (25.6%) were considered chronic NSAID users. Patients chronically assuming NSAADs showed a significantly higher MMSE score than non-users (26.9+/-2.1 vs 25.7+/-2.5, P<0.0005 ). After controlling for potential confounders in a multivariate model, chronic NSAID use remained independently associated with MMSE score. The results support a positive association between chronic NSAID use and cognitive function in non-demented elderly patients. Randomized controlled trials will be needed to definitively prove this beneficial effect.

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Citations

Dec 17, 1997·Movement Disorders : Official Journal of the Movement Disorder Society·E G McGeer, P L McGeer
Oct 31, 2013·Aging Clinical and Experimental Research·Jessica DaganiUNKNOWN Perdove-Anziani Group
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Feb 18, 2012·The Cochrane Database of Systematic Reviews·Darin JaturapatpornNaji Tabet
May 1, 2020·The Cochrane Database of Systematic Reviews·Fionnuala JordanDeclan Devane
Oct 8, 2020·Japan Journal of Nursing Science : JJNS·Sayumi TsuchiyaJunko Sugama

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