Association of CILP2 and ACE gene polymorphisms with cardiovascular risk factors in Slovak midlife women

BioMed Research International
Lenka LuptákováMarta Cvícelová

Abstract

The aim of this study is to assess the association of two polymorphisms, the cartilage intermediate layer protein 2 (CILP2) G/T and angiotensin converting enzyme (ACE) I/D, with blood pressure and anthropometrical and biochemical parameters related to the development of cardiovascular disease. The entire study sample comprised 341 women ranging in age from 39 to 65 years. The CILP2 genotypes were determined by PCR-RFLP and the ACE genotypes by PCR. The Bonferroni pairwise comparisons showed the effect of the CILP2 genotype on high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), apolipoprotein B (apoB), apoB-to-apoA1 ratio, the total cholesterol (TC)-to-HDL-C ratio, non-HDL-C, and the LDL-C-to-HDL-C ratio (P < 0.05). Here, higher mean levels of HDL-C and lower mean levels of the remaining above mentioned lipid parameters were registered in the GT/TT genotype carriers than in GG carriers. Statistically significant association was identified between the ACE genotype and the following parameters: TC, LDL-C, and non-HDL-C (P < 0.05). The II genotype can lower serum level of TC (B = 0.40), LDL-C (B = 0.37), and non-HDL-C levels. The results of this study suggest that the minor T allele of CILP2 g...Continue Reading

References

Feb 1, 1992·Biochemical Society Transactions·J D JohnstonA F Winder
Aug 28, 1999·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·A GiacamanP Rosso
Nov 23, 2000·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·B ZalarR Blinc
Jan 7, 2003·Annals of Internal Medicine·Pasquale StrazzulloUNKNOWN Olivetti Prospective Heart Study
Aug 31, 2004·Arthritis and Rheumatism·Ana M ValdesTim D Spector
Jun 3, 2009·Journal of Medical Genetics·K NakayamaUNKNOWN Jichi Community Genetics Team (JCOG)
Apr 22, 2010·Anthropologischer Anzeiger; Bericht über die biologisch-anthropologische Literatur·Zuzana DankováPavel Blazícek
Feb 19, 2011·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Szilvia FiatalRóza Adány
May 27, 2011·Age·Matea Zajc PetranovićSpomenka Tomek-Roksandić
Aug 9, 2011·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Ke ZhuangLongxian Cheng

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