Association of Circulating Chemerin With Subclinical Parameters of Atherosclerosis: Results of a Population-Based Study

Arteriosclerosis, Thrombosis, and Vascular Biology
Stephanie ZyllaNele Friedrich

Abstract

Chemerin has been shown to be associated with inflammation and metabolic syndrome, which are in turn leading risk factors for atherosclerosis. A few clinical studies have concentrated on the role of chemerin in atherosclerosis but revealed divergent findings. Therefore, we aimed to investigate the association of plasma chemerin levels with different subclinical measurements of atherosclerosis in a population-based sample. Linear and logistic regression models with different atherosclerotic parameters as subclinical outcomes were applied to analyze data from 4003 subjects of the SHIP (Study of Health in Pomerania). After adjustment for metabolic and inflammatory parameters, these models revealed no association of chemerin with carotid intima-media thickness, carotid plaque, or carotid stenosis but a significant inverse association between chemerin and ankle-brachial index. In detail, logistic regression analysis showed that a 25-ng/mL increase in chemerin was associated with a 30% higher odd (95% confidence interval, 1.20-1.41) of having an ankle-brachial index value below the 25th age- and sex-specific quartile. Our analyses revealed a modest inverse association between chemerin and ankle-brachial index that remained consistent...Continue Reading

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Citations

Aug 11, 2019·Clinical Science·Kengo SatoTakuya Watanabe
Mar 28, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Congqing WuHong S Lu
Oct 26, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Elizabeth E Ha, Robert C Bauer
Jul 3, 2021·Medicina·Ioana ParaMihai D Porojan

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