Association of class I and II HLA alleles and haplotypes with susceptibility to vitiligo: a study of patients with vitiligo from southeast Brazil

International Journal of Dermatology
Leandro D RamireFabiana C de Souza-Santana

Abstract

The association of vitiligo with the HLA complex has been previously described in various populations worldwide. However, until now, no similar study has been conducted in Brazil. The aim of this study was to determine the association of HLA alleles with vitiligo in the population of southeast Brazil. DNA samples from 116 patients with vitiligo and 243 healthy controls were obtained using the salting-out technique. HLA class I (A*, B*, C*) and class II (DRB1* and DQB1*) alleles were amplified by polymerase chain reaction with specific oligonucleotide sequences. The case-control study identified susceptibility associations with alleles HLA-A*02 (P = 0.0001, Pc = 0.0020, odds ratio [OR] = 2.68, 95% confidence interval [CI] = 1.69-4.26) and HLA-DRB1*07 (P = 0.0001, Pc = 0.0013, OR = 2.69, 95% CI = 1.66-4.34). The alleles HLA-A*32 (P = 0.0156, Pc = 0.3120, OR = 22.43, 95% CI = 1.12-449.46) and HLA-DQB1*06 (P = 0.0207, Pc = 0.1035, OR = 0.28, 95% CI = 0.10-0.81) were associated with both localized and generalized vitiligo. The haplotype analysis revealed that A*02-B*51-C*15-DRB1*07-DQB1*02 (P = 0.0113), A*02-B*15-C*07-DRB1*13-DQB1*06 (P = 0.0340), and A*29-B*44-C*16-DRB1*07-DQB1*02 (P = 0.0340) were associated with a predisposition ...Continue Reading

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Citations

Oct 1, 2016·BioMed Research International·Zhangjun LiShengxiang Xiao
Sep 12, 2019·Biomolecules·Luciana Veiga-CastelliCelso Mendes-Junior
Oct 10, 2019·HLA : Immune Response Genetics·Juliano A BoquettNelson J R Fagundes
Jan 13, 2021·International Journal of Clinical Practice·Yıldız HayranFüsun Özmen

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