Association of clinicopathological features and prognosis of TERT alterations in phyllodes tumor of breast

Scientific Reports
Julia Y S TsangGary M Tse

Abstract

Phyllodes tumor (PT) of the breast is a rare but clinically important fibroepithelial tumor with potential risks of recurrence and metastasis. Recent studies identified recurrent TERT promoter mutations in PTs. However, the clinical significance of this alteration has not been fully examined. Two hundred and seven PTs from two intuitions were included. All cases were subjected to immunohistochemical analysis for TERT expression. Analysis of TERT promoter mutations was further performed by Sanger sequencing targeting the hotspot mutation region on cases from one of the involved institutions. The expression of TERT was correlated with clinicopathologic features, mutation status and recurrence. There was an association of TERT expression and its promoter mutation. Both stromal TERT expression and its promoter mutation correlated with PT grading and older patient age. Recurrence free survival (RFS) of PT patients with high stromal TERT expression was shorter if the excision margin was positive. Our findings suggested a possible pathogenic role of TERT alteration in PT malignancy. Currently there is no consensus for re-excision for PT patients with positive surgical margin, particularly for low grade cases. Stromal TERT expression c...Continue Reading

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Citations

Aug 15, 2019·The Journal of Pathology·Nur Diyana Md NasirPuay Hoon Tan
Oct 31, 2019·Journal of Clinical Pathology·Huan Ying ChangPuay Hoon Tan
Nov 28, 2020·Human Pathology·Po-Han ChenEmily Reisenbichler
Apr 13, 2021·Breast Cancer Research and Treatment·Julia Y TsangGary M Tse

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Methods Mentioned

BETA
PCR
biopsy
electrophoresis

Software Mentioned

SPSS
Image Lab

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