Association of CMV-Specific T Cell-Mediated Immunity with CMV DNAemia and Development of CMV Disease in HIV-1-Infected Individuals

PloS One
Maximilian C AichelburgKatharina Grabmeier-Pfistershammer

Abstract

Among HIV-1-infected individuals, cytomegalovirus (CMV) reactivation and disease occur in the setting of advanced immunosuppression. The value of a standardized assessment of CMV-specific T-cell mediated immunity by the CMV QuantiFERON assay (CMV-QFT) has not yet been thoroughly investigated in HIV-1-infected subjects. Prospective, longitudinal study in 153 HIV-1-infected subjects with a CD4+ T cell count < 350/μL who simultaneously underwent CMV-QFT, CMV serology testing and CMV-DNA quantification. Factors associated with CMV-QFT were evaluated. Clinical screening for CMV manifestations was then performed every 3 months. Among the 141 CMV IgG-seropositive individuals the CMV-QFT assay yielded reactive results in 84% (118/141), negative results in 15% (21/141) and indeterminate (negative mitogen IFN-gamma response) results in 1% (2/141) of subjects. The mean actual CD4+ T cell count was significantly higher in CMV-QFT reactive subjects, when compared to CMV-QFT non-reactive individuals (183 ± 102 vs. 126 ± 104 cells/μL, P = 0.015). A significantly lower proportion of CMV-QFT reactive vs. non-reactive patients displayed CMV DNAemia > 100 copies/mL (23% (27/118) vs. 48% (11/23), P = 0.02). Furthermore, a statistically significant...Continue Reading

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Citations

Mar 31, 2016·International Journal of Oral Science·Yu-Chen JiangXiu-Rong Guo
Jun 1, 2018·Tropical Medicine & International Health : TM & IH·Helene L GrønborgUNKNOWN Bissau HIV Cohort Study Group
Jun 7, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Maria Grazia CaprettiTiziana Lazzarotto
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Samir Mohamed AwadSamar Said Fatahala

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Methods Mentioned

BETA
ELISA
PCR
enzyme-linked immunosorbent assay

Software Mentioned

SPSS Statistics

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