Association of cognitive dysfunction with cardiovascular disease events in elderly hypertensive patients

Journal of Hypertension
Yuichiro YanoKazuomi Kario

Abstract

This study assesses whether presence of cognitive dysfunction can be a marker associated with the development of cardiovascular disease (CVD) events independent of ambulatory blood pressure (BP) or other indices of target organ damage (TOD) in elderly hypertensive patients. We recruited 585 hypertensive patients (mean age, 73 years; 41% men) who were ambulatory, lived independently, and were without clinically overt dementia. Cognitive function was assessed by Mini-Mental State Examination (MMSE) at baseline, and CVD events (coronary artery disease, stroke, congestive heart failure, and sudden death) were prospectively ascertained. Cognitive dysfunction was defined as the lowest quartile of MMSE scores (n = 183, median 24 points). CVD events occurred in 42 people over an average of 2.8 years (1644 person-years). The prevalence of cognitive dysfunction was higher in patients with CVD events than those without (57 vs. 29%; both P <0.001) at baseline. Cognitive dysfunction was associated with CVD events, after adjustment for nocturnal SBP and evidence of TOD [i.e. albuminuria, cardiac hypertrophy, and carotid-artery intima-media thickness (IMT)], hazard ratio 2.5-2.9 (all P <0.01). Incorporation of MMSE in the risk model (includin...Continue Reading

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Citations

Jan 9, 2019·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·So Yeong Cheon, Kyoung Joo Cho
May 28, 2019·The Journal of Clinical Hypertension·Yuda TuranaKazuomi Kario
Nov 8, 2014·Journal of Hypertension·Bo Carlberg
Jun 11, 2019·Frontiers in Neuroscience·Romina María Uranga, Jeffrey Neil Keller
Jul 22, 2021·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Jiawei QinLiling Zheng

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