Association of Common Genetic Variants With Contralateral Breast Cancer Risk in the WECARE Study

Journal of the National Cancer Institute
Mark RobsonWecare Study Collaborative Group

Abstract

Women with unilateral breast cancer (UBC) are at risk of developing a subsequent contralateral breast cancer (CBC). Common variants are associated with breast cancer risk. Whether these influence CBC risk is unknown. Participants were breast cancer cases from the population-based Women's Environmental Cancer and Radiation Epidemiology (WECARE) Study. Sixty-seven established breast cancer risk loci were genotyped directly or by imputation in 1459 case subjects with CBC and 2126 UBC control subjects. An unweighted polygenic risk score (PRS) was created by summing the number of risk alleles for each directly genotyped single nucleotide polymorphism (SNP), or for imputed loci, the imputed dosage. A weighted PRS was calculated similarly, but where each SNP's contribution was weighted by the published per-allele log odds ratio. Unweighted and weighted polygenic risk scores and CBC risk were modeled using conditional logistic regression. Cumulative CBC risk was estimated and benchmarked using Surveillance, Epidemiology, and End Results population incidence rates. Both unweighted and weighted PRS were statistically significantly associated with CBC risk. The adjusted risk ratio of CBC in women in the upper quartile of unweighted PRS co...Continue Reading

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Citations

Dec 7, 2018·International Journal of Particle Therapy·Lindsay M MortonBarry S Rosenstein
Apr 6, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anne S ReinerJonine L Bernstein
Sep 21, 2018·American Society of Clinical Oncology Educational Book·Lindsay M MortonM Eileen Dolan
Dec 15, 2019·Expert Review of Molecular Diagnostics·Evgeny N Imyanitov, Ekatherina Sh Kuligina
Dec 30, 2020·Journal of the National Cancer Institute·Julika BordeEric Hahnen
Mar 13, 2021·Patient Education and Counseling·Kuheli Das GuptaTatiane Yanes
Apr 8, 2021·Breast Cancer Research and Treatment·Jeffrey N WeitzelThomas P Slavin
Oct 7, 2020·American Journal of Human Genetics·Iris KramerMarjanka K Schmidt
May 28, 2021·British Journal of Cancer·Vasily GiannakeasSteven A Narod
Aug 4, 2021·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Tatiane YanesPaul A James

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