Association of common mitochondrial DNA variants with multiple sclerosis and systemic lupus erythematosus.

Clinical Immunology : the Official Journal of the Clinical Immunology Society
Tamara VyshkinaBernadette Kalman

Abstract

Mitochondrial dysfunction has been implicated in the pathogenesis of multiple sclerosis (MS) and systemic lupus erythematosus (SLE). This study re-investigates the roles of previously suggested candidate genes of energy metabolism (Complex I genes located in the nucleus and in the mitochondria) in patients with MS relative to ethnically matched SLE patients and healthy controls. After stringent correction for multiple testing, we reproduce the association of the mitochondrial (mt)DNA haplotype K* with MS, but reject the importance of previously suggested borderline associations with nuclear genes of Complex I. In addition, we detect the association of common variants of the mitochondrial ND2 and ATP6 genes with both MS and SLE, which raises the possibility of a shared mitochondrial genetic background of these two autoimmune diseases.

References

Jul 1, 1990·Journal of the Neurological Sciences·P A McCombeM P Pender
Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester
Sep 1, 1996·Journal of the Neurological Sciences·B KalmanH Alder
Sep 1, 1996·Acta Neurologica Scandinavica·U Mayr-WohlfartG Rödel
Jan 31, 2002·Arthritis and Rheumatism·Peter GergelyAndras Perl
Jan 13, 2004·Science·Eduardo Ruiz-PesiniDouglas C Wallace
Jun 23, 2004·Trends in Immunology·Andras PerlKatalin Banki
Sep 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gyorgy NagyAndras Perl
Dec 21, 2004·Journal of the Neurological Sciences·Tamara VyshkinaBernadette Kalman
Oct 12, 2005·Neurology·B BielekovaH F McFarland
Apr 26, 2006·Current Neurology and Neuroscience Reports·Bernadette Kalman
Jul 31, 2007·The New England Journal of Medicine·UNKNOWN International Multiple Sclerosis Genetics ConsortiumStephen L Hauser
Jul 8, 2008·Journal of Neuroimmunology·Tamara VyshkinaBernadette Kalman

❮ Previous
Next ❯

Citations

Feb 4, 2011·Neurology·S VenkateswaranUNKNOWN Canadian Pediatric Demyelinating Disease Network
Nov 13, 2013·ASN Neuro·Shweta Mandrekar-ColucciDana M McTigue
May 15, 2013·Journal of the Neurological Sciences·Sasan AndalibYones Pilehvar-Soltanahmadi
Oct 9, 2013·Nature Reviews. Rheumatology·Andras Perl
Jul 28, 2012·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Tiffany N CazaAndras Perl
Jul 10, 2010·Journal of Biomedicine & Biotechnology·E Kassi, P Moutsatsou
Jul 24, 2015·Journal of the Neurological Sciences·Sasan AndalibAlbert Gjedde
May 6, 2014·Frontiers in Neuroendocrinology·S T NgoP A McCombe
Apr 9, 2011·Journal of Neuroimmunology·Judith M Greer, Pamela A McCombe
Jul 3, 2015·Neurology·Gregory J TranahJorge R Oksenberg
Jul 18, 2009·Biochimica Et Biophysica Acta·Peizhong Mao, P Hemachandra Reddy
Feb 1, 2015·Brain : a Journal of Neurology·James D Weisfeld-AdamsFred D Lublin
Jul 28, 2016·Acta neurologica Belgica·Sasan AndalibManouchehr Seyedi Vafaee
Apr 1, 2017·Nature Reviews. Rheumatology·Laurence Morel
May 26, 2017·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Yusuke TakeshimaKazuhiko Yamamoto
Dec 18, 2009·Autoimmunity·Andras Perl
Dec 18, 2018·Multiple Sclerosis : Clinical and Laboratory Research·Kevin R PatelFarrah J Mateen
Dec 5, 2019·Biomedical Reports·Maram Atallah AlharbiMoiz Bakhiet
Sep 12, 2018·Biochemistry. Biokhimii︠a︡·M S KozinO O Favorova
Oct 30, 2018·Frontiers in Neuroscience·Patrick F Chinnery, Aurora Gomez-Duran
Aug 28, 2020·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·A N BoykoO G Kulakova
Jan 18, 2020·Nature Reviews. Rheumatology·Amir Sharabi, George C Tsokos
Apr 25, 2013·Metabolic Brain Disease·Laura LlobetEduardo Ruiz-Pesini
Apr 8, 2020·Immunometabolism·Milena VukelicGeorge C Tsokos
Aug 9, 2020·Journal of Molecular Neuroscience : MN·Tobore Onojighofia Tobore
Oct 18, 2020·International Journal of Molecular Sciences·Michael Webb, Dionisia P Sideris
Nov 17, 2020·Autoimmunity·Kumar Sagar JaiswalBhawna Gupta

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde
J M HwangS S Park
Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
D S MojonS J Greenberg
© 2022 Meta ULC. All rights reserved