Association of common variants identified by recent genome-wide association studies with obesity in Chinese children: a case-control study

BMC Medical Genetics
Hai-Jun WangJun Ma

Abstract

Large-scale genome-wide association studies have identified multiple genetic variants that are associated with elevated body mass index (BMI) or the risk of obesity in Caucasian or Asian populations. We examined whether these variants are individually associated with obesity in Chinese children, and also assessed their cumulative effects and predictive value for obesity risk in Chinese children. We genotyped 40 single nucleotide polymorphisms (SNPs) and conducted association analyses for 32/40 SNPs with an estimated minor allele frequency >1% in 2 030 unrelated Chinese children, including 607 normal-weight, 718 overweight, and 705 obese individuals from two cross-sectional study groups. Logistic regression and linear regression under the additive model were used to examine associations, and the area under the receiver operating characteristic curve (AUCROC) was reported as prediction summary. We identified obesity association for 6 SNPs near SEC16B, RBJ, CDKAL1, TFAP2B, MAP2K5 and FTO (odds ratios (ORs) ranged from 1.19 to 1.41, nominal two-sided P-values < 0.05). Association (Bonferroni corrected) of rs543874 near SEC16B and rs2241423 near MAP2K5 had presumably stronger effects on obesity in Chinese children than in Caucasian ...Continue Reading

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Citations

May 19, 2020·Upsala Journal of Medical Sciences·Sobia Rana, Maha Mobin
Jul 22, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Yang-Ching ChenYungling L Lee
May 29, 2018·Experimental and Therapeutic Medicine·Fang Yang, Yumei Wang
Jul 26, 2019·Scientific Reports·Itziar Lamiquiz-MoneoAna Cenarro
Jul 22, 2018·Nutrition & Diabetes·Venesa SahibdeenZané Lombard
Aug 23, 2018·Frontiers in Endocrinology·Preethi T CherianMohamed Abu-Farha
May 28, 2019·World Journal of Pediatrics : WJP·Ning-Ning ZhaoJun-Fen Fu
Aug 20, 2019·Clinical Endocrinology·Shan-Shan YangTai Hing Lam
Dec 15, 2020·JAMA Pediatrics·Melanie HeitkampMartin Halle
Mar 7, 2021·Ageing Research Reviews·Abdoulaye DianeMohammed Dehbi
Apr 4, 2021·International Journal of Molecular Sciences·Augusto Anguita-RuizFrancisco Javier Ruiz-Ojeda

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Methods Mentioned

BETA
dissection
chip
genotyping

Software Mentioned

Sequenom
GIANT
SPSS
MANTRA
MedCalc
SpectroDESIGNER
Quanto

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