Association of common variants in TNFRSF13B, TNFSF13, and ANXA3 with serum levels of non-albumin protein and immunoglobulin isotypes in Japanese.

PloS One
Wael OsmanYusuke Nakamura

Abstract

We performed a genome-wide association study (GWAS) on levels of serum total protein (TP), albumin (ALB), and non-albumin protein (NAP). We analyzed SNPs on autosomal chromosomes using data from 9,103 Japanese individuals, followed by a replication study of 1,600 additional individuals. We confirmed the previously- reported association of GCKR on chromosome 2p23.3 with serum ALB (rs1260326, P(meta) = 3.1 × 10(-9)), and additionally identified the significant genome-wide association of rs4985726 in TNFRSF13B on 17p11.2 with both TP and NAP (P(meta) = 1.2 × 10(-14) and 7.1 × 10(-24), respectively). For NAP, rs3803800 and rs11552708 in TNFSF13 on 17p13.1 (P(meta) = 7.2 × 10(-15) and 7.5 × 10(-10), respectively) as well as rs10007186 on 4q21.2 near ANXA3 (P(meta) = 1.3 × 10(-9)) also indicated significant associations. Interestingly, TNFRSF13B and TNFSF13 encode a tumor necrosis factor (TNF) receptor and its ligand, which together constitute an important receptor-ligand axis for B-cell homeostasis and immunoglobulin production. Furthermore, three SNPs, rs4985726, rs3803800, and rs11552708 in TNFRSF13B and TNFSF13, were indicated to be associated with serum levels of IgG (P<2.3 × 10(-3)) and IgM (P<0.018), while rs3803800 and rs1155...Continue Reading

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Citations

Nov 20, 2013·Leukemia·G J MorganR S Houlston
Oct 18, 2012·Annual Review of Medicine·Krzysztof KirylukAli G Gharavi
Jan 11, 2013·Journal of Human Genetics·Kyung-Won HongYeonjung Kim
Jul 17, 2013·International Journal of Colorectal Disease·Basem AzabScott W Bloom
Oct 18, 2014·Expert Opinion on Therapeutic Targets·Clarence HaleMurielle M Véniant
Sep 17, 2015·Kidney International·Riccardo MagistroniKrzysztof Kiryluk
Sep 8, 2015·Journal of Proteomics·C LandiP Rottoli
Jan 5, 2017·British Journal of Pharmacology·Andrew P Sage, Ziad Mallat
Jan 13, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Lekha PanditOmar Malik
Nov 18, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Fabio SallustioLoreto Gesualdo
Jul 8, 2017·Current Research in Translational Medicine·Q LinM-S Huang

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Methods Mentioned

BETA
genotyping
Assay

Software Mentioned

mach2qtl
EIGENSTRAT
PLINK
R
Haploview
Haplo Stats package

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