Association of comorbid burden with clinical outcomes after transcatheter aortic valve implantation.

Heart
Rodrigo BagurMamas A Mamas

Abstract

To investigate the association of the CharlsonComorbidity Index (CCI) with clinical outcomes after transcatheter aortic valve implantation (TAVI). Patients undergoing TAVI have high comorbid burden; however, there is limited evidence of its impact on clinical outcomes. Data from 1887 patients from the UK, Canada, Spain, Switzerland and Italy were collected between 2007 and 2016. The association of CCI with 30-day mortality, Valve Academic Research Consortium-2 (VARC-2) composite early safety, long-term survival and length of stay (LoS) was calculated using logistic regression and Cox proportional hazard models, as a whole cohort and at a country level, through a two-stage individual participant data (IPD) random effect meta-analysis. Most (60%) of patients had a CCI ≥3. A weak correlation was found between the total CCI and four different preoperative risks scores (ρ=0.16 to 0.29), and approximately 50% of patients classed as low risk from four risk prediction models still presented with a CCI ≥3. Per-unit increases in total CCI were not associated with increased odds of 30-day mortality (OR 1.09, 95% CI 0.96 to 1.24) or VARC-2 early safety (OR 1.04, 95% CI 0.96 to 1.14) but were associated with increased hazard of long-term mo...Continue Reading

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Citations

Nov 25, 2020·Heart·Shubrandu SanjoyRodrigo Bagur
Jul 6, 2021·Mayo Clinic Proceedings·Shubrandu S SanjoyRodrigo Bagur
Sep 25, 2021·Journal of the American Heart Association·Shubrandu S SanjoyRodrigo Bagur

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