Association of Coprescription of Triptan Antimigraine Drugs and Selective Serotonin Reuptake Inhibitor or Selective Norepinephrine Reuptake Inhibitor Antidepressants With Serotonin Syndrome

JAMA Neurology
Yulia OrlovaElizabeth Loder

Abstract

In 2006, the US Food and Drug Administration (FDA) issued an advisory warning on the risk of serotonin syndrome with concomitant use of triptans and selective serotonin reuptake inhibitor (SSRI) or selective norepinephrine reuptake inhibitor (SNRI) antidepressants, but the true risk of serotonin syndrome in these patients remains unknown. To assess the risk of serotonin syndrome with concomitant use of triptans and SSRI or SNRI antidepressants. This study used electronic health record data from the Partners Research Data Registry (RPDR) to identify patients who had received an International Classification of Diseases, Ninth Revision diagnosis compatible with serotonin syndrome who had been coprescribed triptans and SSRI or SNRI antidepressants in the Greater Boston, Massachusetts, area from January 1, 2001, through December 31, 2014 (14 years). Clinical information was extracted to determine whether the case met formal diagnostic criteria and had coprescription within a calendar year. Both conservative and broad case definitions were used to better characterize the spectrum of risk. Data analysis was performed from November 23, 2016, to July 15, 2017. Incidence of serotonin syndrome. The RPDR search revealed 47 968 (±3) unique ...Continue Reading

Citations

Oct 12, 2018·Journal of Clinical Psychopharmacology·Richard I Shader, David J Greenblatt
Dec 19, 2019·Pharmacogenetics and Genomics·Rachel HuddartTeri E Klein
Feb 25, 2020·Circulation Research·Pei-Chi YangColleen E Clancy
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