Association of cord blood chemokines and other biomarkers with neonatal complications following intrauterine inflammation

PloS One
Yoshikazu OtsuboHiroyuki Moriuchi

Abstract

Intrauterine inflammation has been associated with preterm birth and neonatal complications. Few reports have comprehensively investigated multiple cytokine profiles in cord blood and precisely identified surrogate markers for intrauterine inflammation. To identify the cytokines and surrogate markers associated with intrauterine inflammation and subsequent neonatal complications. We analyzed cord blood samples from 135 patients admitted to the neonatal intensive care unit at Sasebo City General Hospital. We retrospectively determined the associations between the presence of neonatal complications and cord blood cytokines, prenatal factors, and laboratory data at birth. A total of 27 cytokines in the cord blood were measured using a bead-based array sandwich immunoassay. Both Th1 and Th2 cytokine levels were low, whereas the levels of growth factors and chemokines were high. In particular, chemokines IL-8, MCP-1, and MIP-1α were significantly higher in very premature neonates when compared with more mature neonates. In addition, some have been shown to be associated with multiple neonatal complications, including patent ductus arteriosus (PDA), respiratory distress syndrome (RDS), and chronic lung disease (CLD). Similarly, the l...Continue Reading

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Citations

Mar 7, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Hatice Kansu-CelikGamze Sinem Caglar
Apr 28, 2020·BioMed Research International·Piotr SurmiakMałgorzata Baumert
Aug 9, 2020·Critical Care Explorations·Daisuke KatagiriHaruhito Sugiyama
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Nov 4, 2020·European Journal of Pediatrics·Agnes-Sophie FritzChristoph Hünseler
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Dec 12, 2021·Molecular and Cellular Pediatrics·Mitali Sahni, Vineet Bhandari

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Methods Mentioned

BETA
SGA

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