Association of cord blood nevirapine concentration with reported timing of dose and HIV-1 transmission

AIDS
J Brooks JacksonLaura A Guay

Abstract

To correlate nevirapine presence and concentration in cord bloods of infants born to HIV-1 infected women with report of timing of dose and HIV-1 transmission at 6 weeks of age. All available cord blood samples from the infants of mothers enrolled in the HIVNET 012 trial who were randomly assigned to receive either nevirapine or zidovudine at the onset of labor were tested for a nevirapine concentration. Nevirapine was detected in the cord blood of 244 of 259 (94%) infants whose mothers reported they took nevirapine in labor more than 1 h before delivery and in 12 of 13 (92%) infants whose mothers reported they took nevirapine less than 1 h before delivery. The median nevirapine cord blood concentration was 1238 ng/ml [interquartile range (IQR), 905-1474 ng/ml] and 122 ng/ml (IQR, 64-321 ng/ml) for women who reported taking nevirapine more or less than 1 h before delivery, respectively (P < 0.001). The median nevirapine cord blood concentration of infants who were HIV-1 negative at birth, but positive at 6-8 weeks of age (n = 11), was 916 ng/ml (IQR, 737-1245 ng/ml) compared with 1192 ng/ml (IQR, 875-1471 ng/ml) for uninfected infants (n = 236). Cord blood nevirapine concentration correlated well with report of nevirapine admin...Continue Reading

References

Nov 30, 1999·Lancet·C P Hudson, J Moodley
Mar 7, 2000·Journal of Pharmaceutical and Biomedical Analysis·J W PavD J Korpalski
Jul 13, 2004·The New England Journal of Medicine·Gonzague JourdainUNKNOWN Perinatal HIV Prevention Trial Group

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Citations

Aug 16, 2008·American Journal of Public Health·Allison SpensleyUNKNOWN Elizabeth Glaser Pediatric AIDS Foundation Prevention of Mother-to-Child Transmission of HIV Group

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