Association of core promoter/precore mutations and viral load in e antigen-negative chronic hepatitis B patients

Journal of Viral Hepatitis
Y-H HuangS-D Lee

Abstract

Apart from core promoter A1762T/G1764A and precore G1896A mutations, other hepatitis B virus (HBV) mutants are detected in hepatitis B e antigen (HBeAg)-negative chronic hepatitis B (CHB). The aim of this study was to determine the effects of those mutants on clinical manifestation and viral loads of genotypes B and C HBV. Seventy-nine HBeAg-negative CHB patients with hepatitis flare were enrolled in this study and their HBV precore/core region were sequenced. Serial biochemical profiles and viral loads were assessed and compared. Fifty-three patients (67%) were infected by genotype B HBV and 26 (33%) were infected by genotype C HBV. The clinical manifestation and HBV viral loads were comparable between the two groups. However, genotype B was significantly associated with precore G1896A mutation (92.5%), and more mutations within nucleotide 1809-1817 were detected in patients infected by genotype B as compared with those infected by genotype C (18.9%vs 3.8%). Most of the cases had mutations at the -2, -3 or -5 position from the precore AUG initiation codon. Triple core promoter mutations T1753C/A1762T/G1764A [corrected] appeared to be linked to genotype C rather than genotype B HBV (19.2%vs 1.9%; P = 0.013). In multivariate ana...Continue Reading

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Citations

Oct 11, 2008·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Shoichi KatsutaYasuyuki Takeda
Oct 11, 2008·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Hajime OhtaniMiyuki Kumai
Oct 7, 2008·World Journal of Gastroenterology : WJG·Tao ShenHong Dong
Nov 14, 2013·World Journal of Gastroenterology : WJG·Francisco Rodriguez-FriasMaria Homs
May 29, 2009·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Patricia Ribeiro de OliveiraMarisa Márcia Mussi-Pinhata
Jun 19, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·I-Cheng LeeShou-Dong Lee
Jul 21, 2006·Journal of Hepatology·Emanuel K Manesis
Sep 15, 2009·Journal of Hepatology·Jaw-Ching WuWing-Yiu Lui
May 27, 2011·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·I-Cheng LeeShou-Dong Lee
Sep 14, 2010·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Jee Hoon HanWon-Yong Lee

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