Association of CTLA-4 polymorphisms and clinical-immunologic characteristics at onset of type 1 diabetes mellitus in children

Human Immunology
Iván BalicFrancisco Pérez-Bravo

Abstract

CTLA-4 is a homeostatic regulator of T cell activation and is believed to play a critical role in immune tolerance. Polymorphisms in the CTLA-4 promoter (-318C/T) and in exon 1 (+49 A/G) were analyzed in 300 Chilean patients with type 1 diabetes mellitus (T1D) and 310 healthy children by polymerase chain reaction-restriction fragment length polymorphism. The effect of CTLA-4 allele and haplotype frequencies on the interferon-gamma, tumor necrosis factor-alpha, and transforming growth factor-beta(1) levels and the presence in serum of GAD65 and IA-2 autoantibodies at the onset of T1D was evaluated. The distribution of the CTLA-4 allele and genotype frequencies was found to be similar in patients and control children. However, among the T1D patients' carriers of GG genotype on CTLA-4 gene a higher frequency of anti-GAD65 autoantibodies (87.2%) was observed. On the other hand, higher ketoacidosis at onset, younger age at onset, and higher levels of tumor necrosis factor-alpha and interferon-gamma were observed in T1D patients carriers of G allele in comparison with the carriers of AA genotype. In conclusion, the result of this study showed that CTLA-4 +49 A/G and -318 C/T polymorphisms were not linked with a higher genetic risk fo...Continue Reading

References

May 1, 2001·Journal of Pediatric Endocrinology & Metabolism : JPEM·Y J LeeJ G Chang
Jun 27, 2001·Genes and Immunity·A LigersJ Hillert
Apr 9, 2002·Journal of Endocrinological Investigation·T KoukiL J Degroot
May 29, 2002·Diabetologia·E A M Gale
Aug 14, 2002·Annals of Medicine·Heikki Hyöty
Nov 28, 2002·Diabetes·Edwin A M Gale
Mar 5, 2003·Annual Review of Immunology·P Anton van der Merwe, Simon J Davis
Apr 30, 2003·Diabetes·Polly J BingleyPatricia W Mueller
Dec 18, 2003·Annals of the New York Academy of Sciences·M A MyersP Z Zimmet
May 11, 2004·European Journal of Endocrinology·Bijay Vaidya, Simon Pearce
Jun 18, 2005·American Journal of Epidemiology·Fotini K Kavvoura, John P A Ioannidis
Oct 18, 2005·Current Opinion in Immunology·Lisa M Maier, Linda S Wicker
Nov 10, 2005·Journal of Autoimmunity·Jean-François Bach
Mar 23, 2006·Annual Review of Immunology·Wendy A TeftJoaquín Madrenas
May 16, 2006·Seminars in Immunology·Nunzio BottiniTomas Mustelin
Oct 26, 2006·The Journal of Clinical Endocrinology and Metabolism·Jian WangLiping Yu
Nov 30, 2006·Diabetes Research and Clinical Practice·Diego GarcíaFrancisco Pérez-Bravo
Nov 9, 2007·Current Opinion in Allergy and Clinical Immunology·David L Duffy

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Citations

Sep 27, 2012·Genetic Testing and Molecular Biomarkers·Xiaoyu SiWenru Tang
Aug 22, 2012·Human Immunology·Jannet SvenssonUNKNOWN Danish Childhood Diabetes Registry
Jul 14, 2009·Diabetes Research and Clinical Practice·Bárbara AngelFrancisco Pérez-Bravo
Sep 7, 2012·The Journal of Investigative Dermatology·Heather M GibsonHenry K Wong
Sep 20, 2015·International Journal of Immunogenetics·N KumarS C Zucman
May 28, 2011·Immunological Investigations·Youssef M MosaadBasem S El-Deek
Mar 6, 2018·Cellular & Molecular Immunology·Peng Zhang, Qianjin Lu
Sep 26, 2020·Therapeutic Advances in Endocrinology and Metabolism·Liyan LiJunxia Yu
Apr 1, 2018·Biochemical Genetics·Ravi Padma-MaliniKaruppiah Balakrishnan
Jan 24, 2021·Immunology and Cell Biology·Melanie R ShapiroTodd M Brusko
Mar 23, 2021·Global Medical Genetics·Khalid E Khalid Kheiralla
Oct 2, 2021·Seminars in Immunopathology·Ana Márquez, Javier Martín

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