Association of culture medium with growth, weight and cardiovascular development of IVF children at the age of 9 years

Human Reproduction
H ZandstraAafke P A van Montfoort

Abstract

Is embryo culture media used during an IVF/ICSI treatment associated with differences in growth, body composition and cardiovascular development as determined in 9-year-old singleton IVF children? The choice of in vitro culture medium for human embryos is associated with differences in body weight, BMI, truncal adiposity, waist circumference and waist/hip ratio at the age of 9, while no significant differences were observed in cardiovascular development. Children born after IVF/ICSI have an increased risk of low birthweight, which is correlated with a higher risk of cardiovascular diseases. Some studies show that IVF children exhibit a significantly higher systolic and diastolic blood pressure and higher fasting glucose levels compared to naturally conceived children. After alternating assignment to G1™ Version 3 (Vitrolife) or K-SICM (Cook) embryo culture media, birthweight of the resulting children was significantly higher in the Vitrolife group and they remained heavier during the first 2 years of life. In this observational cohort study (MEDIUM-KIDS), parents of singletons from a previous study were approached for further follow-up after the ninth birthday of their child. The singletons were born after fresh embryo transfer...Continue Reading

References

Aug 3, 2004·Pediatrics·UNKNOWN National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents

❮ Previous
Next ❯

Citations

Feb 13, 2019·Human Reproduction Update·Sine BerntsenAnja Pinborg
Feb 27, 2019·Human Reproduction Update
Feb 2, 2019·The Journal of Endocrinology·Miguel A VelazquezAdam J Watkins
Aug 1, 2019·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Tatyana N IgoninaSergey Ya Amstislavsky
Feb 14, 2020·Human Reproduction·L DelarocheP Humaidan
Jul 3, 2019·Reproductive Biology and Endocrinology : RB&E·Liang ZhaoLifang Sun
Jan 29, 2020·Human Reproduction Open·Aafke P A Van MontfoortJannie Van Echten-Arends
Mar 22, 2019·Human Reproduction Open·H ZandstraA P A van Montfoort
Aug 17, 2020·The Cochrane Database of Systematic Reviews·Charalampos S SiristatidisDennis Vaidakis
Oct 3, 2020·Human Reproduction Open·UNKNOWN Annual Capri Workshop Group
Nov 20, 2020·International Journal of Molecular Sciences·Francisco Marco-JiménezJosé S Vicente
Mar 3, 2021·Journal of Perinatology : Official Journal of the California Perinatal Association·Dmitry DukhovnyJudy E Stern

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.